THYROID CARCINOMA, PAPILLARY

General Information (adopted from Orphanet):

Synonyms, Signs: PAPILLARY CARCINOMA OF THYROID
NONMEDULLARY THYROID CARCINOMA, PAPILLARY
FAMILIAL NONMEDULLARY THYROID CANCER, PAPILLARY
PACT
PTC
TPC
Number of Symptoms 4
OrphanetNr:
OMIM Id: 188550
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0002895) Papillary thyroid carcinoma 10 / 7739
2
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
3
(OMIM) Reported colon and other abdominal cancer in relatives 1 / 7739
4
(OMIM) Frequent inv(10)(q11.2q21) producing chimeric transforming sequence RET/PTC 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases (summary by Vriens et al., 2009). The remaining cancers originate from parafollicular cells (medullary thyroid cancer, ...
Clinical Description OMIM Lote et al. (1980) identified 2 kindreds with 7 and 4 cases of papillary carcinoma in otherwise healthy, nonirradiated subjects. All grew up in 1 of 2 small fishing villages in northern Norway. The familial cases showed an ...
Genotype-Phenotype Correlations OMIM Sugg et al. (1998) examined the expression of RET/PTC-1, -2, and -3 in human thyroid microcarcinomas and clinically evident PTC to determine its role in early-stage versus developed PTC and to examine the diversity of RET/PTC in multifocal ...
Molecular genetics OMIM Kimura et al. (2003) identified a val600-to-glu (V600E; 164757.0001) mutation in the BRAF gene in 28 (35.8%) of 78 cases of PTC; it was not found in any of the other types of differentiated follicular neoplasms arising from ...
Population genetics OMIM The world's highest incidence of thyroid cancer has been reported among females in New Caledonia, a French overseas territory in the Pacific located between Australia and Fiji. Chua et al. (2000) investigated the prevalence and distribution of RET/PTC ...