SCHIZOPHRENIA

General Information (adopted from Orphanet):

Synonyms, Signs: SCHIZOAFFECTIVE DISORDER, INCLUDED
SCZD
Number of Symptoms 10
OrphanetNr:
OMIM Id: 181500
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
Heterogeneous
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0007086) Social and occupational deterioration 2 / 7739
2
(HPO:0002353) EEG abnormality 25% [HPO] 188 / 7739
3
(HPO:0000746) Delusions 21 / 7739
4
(HPO:0100753) Schizophrenia 20 / 7739
5
(HPO:0000738) Hallucinations 60 / 7739
6
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
7
(OMIM) Disorganized speech 1 / 7739
8
(OMIM) Catatonic behavior 1 / 7739
9
(HPO:0001425) Heterogeneous 132 / 7739
10
(OMIM) Abnormal EEG in 25% hospitalized patients 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Schizophrenia is a psychosis, a disorder of thought and sense of self. Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and ...
Clinical Description OMIM Schizophrenia often develops in young adults who were previously normal, and is characterized by a constellation of symptoms including hallucinations and delusions (psychotic symptoms) and symptoms such as severely inappropriate emotional responses, disordered thinking and concentration, erratic behavior, ...
Molecular genetics OMIM Using data from a regularly updated online database of all published genetic association studies for schizophrenia (SzGene), Allen et al. (2008) carried out random-effects metaanalyses for all polymorphisms having genotype data available in at least 4 independent case-control ...
Population genetics OMIM If a narrow diagnostic definition is used, the lifetime morbid risk of schizophrenia does not vary far from 1% (range 0.7-1.4%) in a wide variety of geographic regions (Jablensky et al., 1992). A higher incidence has been found ...