RHEUMATOID ARTHRITIS

General Information (adopted from Orphanet):

Synonyms, Signs: RHEUMATOID ARTHRITIS, SUSCEPTIBILITY TO
RA
Number of Symptoms 12
OrphanetNr:
OMIM Id: 180300
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000707) Abnormality of the nervous system 61 / 7739
2
(HPO:0001370) Rheumatoid arthritis 12 / 7739
3
(HPO:0002633) Vasculitis 12 / 7739
4
(HPO:0001871) Abnormality of blood and blood-forming tissues 37 / 7739
5
(HPO:0002086) Abnormality of the respiratory system 17 / 7739
6
(HPO:0002715) Abnormality of the immune system 46 / 7739
7
(MedDRA:10048694) Rheumatoid nodule 1 / 7739
8
(OMIM) Felty syndrome 1 / 7739
9
(MedDRA:10048628) Rheumatoid vasculitis 1 / 7739
10
(OMIM) Rheumatoid lung disease 1 / 7739
11
(OMIM) HLA-DRB1 association 1 / 7739
12
(OMIM) Rheumatoid vasculitic mononeuritis 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component.
Molecular genetics OMIM Patients with vascular complications of RA have an expansion of CD4 (186940)-positive/CD28 (186760)-null T cells that may be involved in endothelial cell damage. By flow cytometric and RT-PCR analyses, Yen et al. (2001) showed that CD4-positive/CD28-null T-cell clones ...