PSORIASIS 1, SUSCEPTIBILITY TO

General Information (adopted from Orphanet):

Synonyms, Signs: PSORS1
Number of Symptoms 15
OrphanetNr:
OMIM Id: 177900
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Multifactorial
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0005059) Arthralgia/arthritis 141 / 7739
2
(HPO:0002758) Osteoarthritis 78 / 7739
3
(HPO:0001369) Arthritis 44 / 7739
4
(HPO:0003765) Psoriasis 17 / 7739
5
(HPO:0001806) Onycholysis 20 / 7739
6
(HPO:0001803) Nail pits 17 / 7739
7
(OMIM) Epidermal hyperproliferation 1 / 7739
8
(OMIM) Red, raised, scaly skin patches (elbows, knees, scalp) 1 / 7739
9
(OMIM) Lymphocytic inflammatory infiltrate 1 / 7739
10
(OMIM) Abnormal keratinocyte differentiation 1 / 7739
11
(MedDRA:10049274) Onychomadesis 1 / 7739
12
(HPO:0001426) Multifactorial inheritance 37 / 7739
13
(MedDRA:10048649) Koebner phenomenon 1 / 7739
14
(OMIM) HLA antigens CW6, B13, B17 associated with psoriasis 1 / 7739
15
(OMIM) Dystrophic nail changes 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Psoriasis is a chronic inflammatory dermatosis that affects approximately 2% of the population. It is characterized by red, scaly skin patches that are usually found on the scalp, elbows, and knees, and may be associated with severe arthritis. ...
Molecular genetics OMIM - HLA Association Studies

Gudjonsson et al. (2002) typed 369 patients with familial psoriasis for HLA-C and compared the clinical features of the patients carrying HLA-Cw6 with those carrying other HLA-C types. Patients who are Cw6-positive ...