PELVIC ORGAN PROLAPSE, SUSCEPTIBILITY TO

General Information (adopted from Orphanet):

Synonyms, Signs: PROLAPSE OF VAGINA AND RECTUM
RECTAL PROLAPSE
PVOP1, INCLUDED
VAGINAL PROLAPSE PELVIC ORGAN PROLAPSE, SUSCEPTIBILITY TO, 1, INCLUDED
Number of Symptoms 5
OrphanetNr:
OMIM Id: 176780
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0002035) Rectal prolapse 11 / 7739
2
(HPO:0002607) Bowel incontinence 33 / 7739
3
(MedDRA:10046940) Vaginal prolapse 1 / 7739
4
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
5
(OMIM) Late fecal incontinence 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the ...
Clinical Description OMIM Yip and Kirsner (1983) described a 69-year-old woman who developed vaginal prolapse at age 29 for which vaginal hysterectomy was performed, and rectal prolapse at age 57 for which Dolorme operation was performed at age 62. At age ...
Population genetics OMIM Ethnic and racial variations in the incidence of female pelvic floor disorders support the role of genetic factors. Women of European and Hispanic descent may be at greater risk compared to women of Asian, African, and Native American ...