ACTINIC PRURIGOPOLYMORPHIC LIGHT ERUPTION, HEREDITARY

General Information (adopted from Orphanet):

Synonyms, Signs: JUVENILE SPRING ERUPTION OF EARS, INCLUDED
HPLE
Number of Symptoms 11
OrphanetNr:
OMIM Id: 174770
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000099) Glomerulonephritis 13 / 7739
2
(HPO:0100825) Cheilitis 20 / 7739
3
(HPO:0000992) Cutaneous photosensitivity 75 / 7739
4
(HPO:0000999) Pyoderma 7 / 7739
5
(MedDRA:10041303) Solar dermatitis 1 / 7739
6
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
7
(OMIM) Glomerulonephritis can follow streptococcal pyoderma 1 / 7739
8
(OMIM) Fissured, crusted exudative cheilitis 1 / 7739
9
(MedDRA:10000616) Actinic prurigo 1 / 7739
10
(OMIM) Eczematous crusted eruptions on face and arms 1 / 7739
11
(OMIM) Hydroa aestivale 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Hereditary polymorphic light eruption is a form of photosensitivity found in the American Indians of the central plains of Canada and the United States and in the Indians of Central and South America. The disorder has also been ...
Clinical Description OMIM Some hours after sun exposure, actinic prurigo patients experience an intense pruritus and develop a dermatosis on the face and exposed areas. Skin signs include erythematous weeping areas, vesicles, papules, nodules, and plaques. Excoriations are common. The lips ...