HYPERTROPHIC OSTEOARTHROPATHY, PRIMARY, AUTOSOMAL DOMINANT

General Information (adopted from Orphanet):

Synonyms, Signs: PACHYDERMOPERIOSTOSIS, AUTOSOMAL DOMINANT
PDP, AUTOSOMAL DOMINANT
PHO, AUTOSOMAL DOMINANT
PHOAD
Number of Symptoms 10
OrphanetNr:
OMIM Id: 167100
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
 (HPO:0100759) Clubbing of fingers 40 / 7739
2
 (HPO:0000975) Hyperhidrosis 64 / 7739
3
 (MedDRA:10057178) Osteoarthropathies 1 / 7739
4
 (OMIM) Occasional ptosis 1 / 7739
5
 (OMIM) Cutis gyrata 2 / 7739
6
 (MedDRA:10031173) Osteoarthropathy 1 / 7739
7
 (OMIM) Seborrheic hyperplasia 1 / 7739
8
 (OMIM) Coarse skin 2 / 7739
9
 (OMIM) Thickened periosteum of distal limb bones 1 / 7739
10
 (OMIM) Cutis verticis gyrata latens 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Touraine et al. (1935) recognized pachydermoperiostosis (PDP) as a familial disorder with 3 presentations or forms: a complete form with periostosis and pachydermia, an incomplete form without pachydermia, and a forme fruste with pachydermia and minimal skeletal changes. ...