OSTEOARTHRITIS SUSCEPTIBILITY 1

General Information (adopted from Orphanet):

Synonyms, Signs: OSTEOARTHRITIS OF HIP, FEMALE-SPECIFIC, SUSCEPTIBILITY TO
OSTEOARTHROSIS
OS1
OA
Number of Symptoms 7
OrphanetNr:
OMIM Id: 165720
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
Autosomal recessive inheritance
Heterogeneous
Multifactorial
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0008843) Hip osteoarthritis 12 / 7739
2
(HPO:0002644) Abnormality of pelvic girdle bone morphology 31 / 7739
3
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
4
(HPO:0001426) Multifactorial inheritance 37 / 7739
5
(HPO:0001425) Heterogeneous 132 / 7739
6
(HPO:0000007) Autosomal recessive inheritance 2538 / 7739
7
(OMIM) Early onset osteoarthritis 3 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Osteoarthritis (OA) is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis (Meulenbelt et al., 2006). Clinical problems include pain and joint stiffness often leading ...
Molecular genetics OMIM - Variation in FRZB

Using microsatellite targeting of 8 candidate genes spanning the 2q23-q32 region with known roles in skeletal development or homeostasis, Loughlin et al. (2004) found association of hip osteoarthritis with the TNFAIP6 (600410) ...