NAIL DISORDER, NONSYNDROMIC CONGENITAL, 5

General Information (adopted from Orphanet):

Synonyms, Signs: ONYCHOLYSIS, PARTIAL, WITH SCLERONYCHIA
ONYCHOLYSIS, HEREDITARY DISTAL
NDNC5
Number of Symptoms 11
OrphanetNr:
OMIM Id: 164800
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0007410) Palmoplantar hyperhidrosis rare [HPO:skoehler] 6 / 7739
2
(HPO:0008400) Onycholysis of distal fingernails 2 / 7739
3
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
4
(OMIM) Onycholysis of distal nails 1 / 7739
5
(OMIM) Absent lunulae, except on thumbs 1 / 7739
6
(OMIM) Discoloration of distal nails 1 / 7739
7
(OMIM) Increased transverse curvature in some nails 1 / 7739
8
(OMIM) Fissures of soles (in some patients) 1 / 7739
9
(OMIM) Scleronychia (induration and thickening of nails) 1 / 7739
10
(OMIM) Sensitivity to cold with paresthesias 1 / 7739
11
(OMIM) Slowing of nail growth 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Hereditary distal onycholysis is an autosomal dominant nail disorder characterized by a decreased rate of growth of the nail, scleronychia, and a straight or concave proximal edge of detachment. Clinical features may include palmoplantar hyperhydrosis and marked sensitivity ...
Clinical Description OMIM Schulze (1966) described a mother and 2 children with onycholysis of the distal part of the fingernails, which were thickened. The disease was thought to have occurred in 5 generations. Bazex et al. (1990) stated that all fingernails ...