Chromosomal mosaicism as described here refers to a tendency to chromosomal nondisjunction. See also premature chromatid separation (PCS; 165430), which may also predispose to chromosomal nondisjunction.
Hecht et al. (1964) reviewed evidence on the nonrandomness of chromosomal abnormalities, including Down syndrome (190685) and trisomy 18.
Hirschhorn (1968) and Weiner (1965) reported familial mosaicism. A 65-year-old man with classic chronic myeloid leukemia (CML; ... Hecht et al. (1964) reviewed evidence on the nonrandomness of chromosomal abnormalities, including Down syndrome (190685) and trisomy 18. Hirschhorn (1968) and Weiner (1965) reported familial mosaicism. A 65-year-old man with classic chronic myeloid leukemia (CML; 608232) had the Philadelphia chromosome in all bone marrow and peripheral blood cells. His father died of leukemia of undetermined type and a brother and sister died of well-documented CML without chromosome studies. Three healthy offspring of the proband demonstrated mosaicism for the Philadelphia chromosome in peripheral blood cells. Grell (1971) referred to 'distributive pairing' as a phenomenon occurring in man to explain aneuploidy. Baker et al. (1976) reviewed the evidence for meiotic mutants in man against the large body of information on such mutants in other species.