MACROGLOBULINEMIA, WALDENSTROM, SUSCEPTIBILITY TO, 1

General Information (adopted from Orphanet):

Synonyms, Signs: WM1 MACROGLOBULINEMIA, WALDENSTROM, SOMATIC, INCLUDED
Number of Symptoms 5
OrphanetNr:
OMIM Id: 153600
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0001271) Polyneuropathy 56 / 7739
2
(HPO:0003347) Impaired lymphocyte transformation with phytohemagglutinin 6 / 7739
3
(HPO:0005508) Waldenstrom macroglobulinemia 2 / 7739
4
(HPO:0003459) Polyclonal elevation of IgM 4 / 7739
5
(OMIM) Increased frequency of lymphoma, leukemia, and adenocarcinom of lung 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Waldenstrom macroglobulinemia (WM) is a malignant B-cell neoplasm characterized by lymphoplasmacytic infiltration of the bone marrow and hypersecretion of monoclonal immunoglobulin M (IgM) protein (review by Vijay and Gertz, 2007). The importance of genetic factors is suggested by ...
Clinical Description OMIM The clinical features of Waldenstrom macroglobulinemia are variable, and many patients have asymptomatic or indolent disease. Symptoms are attributable to the extent of tumor infiltration, resulting in anemia or cytopenia when in the bone marrow, as well as ...
Molecular genetics OMIM By microRNA-expression profiling of bone marrow-derived CD19(+) WM cells, Roccaro et al. (2009) identified a specific microRNA signature characterized by increased expression of 6 microRNAs, including MIR155 (609337), MIR363, MIR206 (611599), MIR494, MIR184 (613146), and MIR542-3p. Further study ...