LEUKEMIA, CHRONIC LYMPHOCYTIC

General Information (adopted from Orphanet):

Synonyms, Signs: LEUKEMIA, CHRONIC LYMPHATIC
CLL
Number of Symptoms 6
OrphanetNr:
OMIM Id: 151400
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant somatic cell mutation
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0005550) Chronic lymphatic leukemia 5 / 7739
2
(HPO:0005374) Cellular immunodeficiency 5 / 7739
3
(HPO:0001444) Autosomal dominant somatic cell mutation 4 / 7739
4
(OMIM) Impaired cellular and humoral immunity 1 / 7739
5
(OMIM) Recurring t(11,14) and t(14,19)(q32,q13.1) translocations 1 / 7739
6
(HPO:0001428) Somatic mutation 100 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Chronic lymphocytic leukemia (CLL) is a common neoplasia of B lymphocytes in which these cells progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent ...
Clinical Description OMIM Wiley et al. (2002) noted that CLL is the most frequent type of leukemia in the developed world and results in the progressive accumulation of mature CD5 (153340)-positive B lymphocytes in blood and bone marrow of the affected ...
Molecular genetics OMIM Puente et al. (2011) performed whole-genome sequencing of 4 cases of CLL and identified 46 somatic mutations that potentially affect gene function. Further analysis of these mutations in 363 patients with CLL identified 4 genes that are recurrently ...
Population genetics OMIM Hamblin (2004) pointed out that with sensitive techniques, a monoclonal population of B lymphocytes that is indistinguishable from CLL cells may be found in the blood of 3.5% of persons older than 40 years of age.