LEG ULCERS, FAMILIAL, OF JUVENILE ONSET

General Information (adopted from Orphanet):

Synonyms, Signs:
Number of Symptoms 7
OrphanetNr:
OMIM Id: 150590
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Male-limited autosomal dominant
[Omim]
Age of onset: Juvenile onset
[Omim]

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0200042) Skin ulcer 138 / 7739
2
(HPO:0000951) Abnormality of the skin 147 / 7739
3
(HPO:0001626) Abnormality of the cardiovascular system 73 / 7739
4
(OMIM) No venous insufficiency 1 / 7739
5
(HPO:0003621) Juvenile onset 105 / 7739
6
(HPO:0001475) Male-limited autosomal dominant 2 / 7739
7
(OMIM) No varicosities 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM In an Iraqi Jewish family, Winkler et al. (1991) observed 11 males in 7 sibships with leg ulcers of early onset. The 27-year-old propositus, for example, had bilateral, recurrent, lateral and medial malleolar leg ulcers that had first ...