KLEEBLATTSCHAEDEL

General Information (adopted from Orphanet):

Synonyms, Signs: CLOVERLEAF SKULL
KLEEBLATTSCHADEL
Number of Symptoms 7
OrphanetNr:
OMIM Id: 148800
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
Sporadic
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0001363) Craniosynostosis 132 / 7739
2
(HPO:0000520) Proptosis 192 / 7739
3
(HPO:0000495) Recurrent corneal erosions 20 / 7739
4
(HPO:0003070) Elbow ankylosis 8 / 7739
5
(OMIM) Premature coronal and lambdoidal suture closure 1 / 7739
6
(OMIM) Trilobular skull 1 / 7739
7
(HPO:0000238) Hydrocephalus 278 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Cloverleaf skull, or Kleeblattschaedel, consists of a trilobular skull with craniosynostosis. The condition shows pathogenetic variability and etiologic heterogeneity. The cause of isolated cloverleaf skull is unknown (Cohen, 2009).

Cohen (1975) pointed out that Kleeblattschaedel is ...