CDH, INCLUDED
HIP DYSPLASIA, CONGENITAL, NONSYNDROMIC, INCLUDED
CONGENITAL DYSPLASIA OF THE HIP, INCLUDED
DEVELOPMENTAL DYSPLASIA OF HIP, INCLUDED
DISLOCATION OF HIP, CONGENITAL, INCLUDED
Acetabular dysplasia is an idiopathic, localized developmental dysplasia of the hip that is characterized by a shallow hip socket and decreased coverage of the femoral head (Mabuchi et al., 2006). Its radiologic criteria include the center-edge angle of ... Acetabular dysplasia is an idiopathic, localized developmental dysplasia of the hip that is characterized by a shallow hip socket and decreased coverage of the femoral head (Mabuchi et al., 2006). Its radiologic criteria include the center-edge angle of Wiberg, the Sharp angle, and the acetabular roof obliquity. Most patients with acetabular dysplasia develop osteoarthritis (165720) after midlife, and even mild acetabular dysplasia can cause hip osteoarthritis.
Mabuchi et al. (2006) described a large Japanese family in which acetabular dysplasia inherited as an autosomal dominant was the basis of osteoarthritis of the hip joint. Eight individuals in 4 generations had acetabular dysplasia manifested as pain ... Mabuchi et al. (2006) described a large Japanese family in which acetabular dysplasia inherited as an autosomal dominant was the basis of osteoarthritis of the hip joint. Eight individuals in 4 generations had acetabular dysplasia manifested as pain in the hip joint during adolescence and progressing to severely crippling hip osteoarthritis before age 60 years. The patients were in general good health, height was not reduced, and there was no skeletal involvement suggestive of chondrodysplasia. Hip osteoarthritis was indistinguishable from that of idiopathic nonfamilial osteoarthritis associated with acetabular dysplasia. The family's phenotype resembled that of Beukes familial hip dysplasia (142669) in that both exhibited shallow acetabula and eventual osteoarthritis. However, the later onset of symptoms, lack of deformity in the femoral head and/or greater trochanter, and absence of broadening of the femoral neck distinguished the phenotype of the Japanese family from that of Beukes familial hip dysplasia. - Congenital Dysplasia of the Hip Congenital dysplasia of the hip (CDH) is an abnormality of the seating of the femoral head in the acetabulum (Sollazzo et al., 2000). Its severity ranges from mild instability of the femoral head with slight capsular laxity, through moderate lateral displacement of the femoral head, without loss of contact of the head with the acetabulum, up to complete dislocation of the femoral head from the acetabulum. It is one of the most common skeletal congenital anomalies. CDH occurs as an isolated anomaly or with more general disorders represented by several syndromes and with chromosomal abnormalities such as trisomy 18 (Wynne-Davies, 1970). Dislocation of the hip is an occasional feature of conditions with simple inheritance, e.g., Marfan syndrome (154700) and Ehlers-Danlos syndrome (see 130000). Beukes familial hip dysplasia is inherited as an autosomal dominant and maps to chromosome 4q35 (Cilliers and Beighton, 1990).
There is a great discrepancy in the frequency of CDH according to geographic and ethnic differences. In general, CDH is more frequent in whites than in blacks and Chinese (Weinstein, 1987; Wilkinson, 1992). For Caucasian populations, an incidence ... There is a great discrepancy in the frequency of CDH according to geographic and ethnic differences. In general, CDH is more frequent in whites than in blacks and Chinese (Weinstein, 1987; Wilkinson, 1992). For Caucasian populations, an incidence of 1 per 1,000 live births can be assumed (Warkany, 1985). Record and Edwards (1958) estimated the risk of recurrence in subsequently born sibs to be about 5%. CDH, often bilateral, is more frequent in females than in males, with a 5:1 ratio (Weinstein, 1987). Joint laxity, normally greater in females than in males, probably accounts for the preponderance of affected females over males.