GILLES DE LA TOURETTE SYNDROME

General Information (adopted from Orphanet):

Synonyms, Signs: TOURETTE SYNDROME
TOURETTE DISORDER CHRONIC MOTOR TICS, INCLUDED
TS
GTS
Number of Symptoms 11
OrphanetNr:
OMIM Id: 137580
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0010529) Echolalia 20 / 7739
2
(HPO:0007018) Attention deficit hyperactivity disorder 56 / 7739
3
(HPO:0002360) Sleep disturbance 113 / 7739
4
(HPO:0000718) Aggressive behavior 109 / 7739
5
(HPO:0000722) Obsessive-compulsive behavior 35 / 7739
6
(HPO:0100035) Phonic tics 1 / 7739
7
(HPO:0000742) Self-mutilation 27 / 7739
8
(HPO:0100034) Motor tics 5 / 7739
9
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
10
(MedDRA:10010964) Coprolalia 1 / 7739
11
(OMIM) Motor and vocal tics 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Tourette syndrome is a neurobehavioral disorder manifest particularly by motor and vocal tics and associated with behavioral abnormalities. Tics are sudden, brief, intermittent, involuntary or semi-voluntary movements (motor tics) or sounds (phonic or vocal tics). They typically consist ...
Clinical Description OMIM Gilles de la Tourette (1885) first described this disorder as a nervous affliction characterized by motor incoordination accompanied by echolalia and coprolalia (see HISTORY).

Kurlan et al. (1986) reported on a large Mennonite kindred from Alberta ...

Molecular genetics OMIM - Mutation in the HDC Gene

By genomewide linkage analysis followed by candidate gene sequencing in a large 2-generation family with Gilles de la Tourette syndrome, Ercan-Sencicek et al. (2010) identified a heterozygous nonsense mutation in ...

Population genetics OMIM Kurlan et al. (1987) cited a prevalence of 28.7 per 100,000 in school children of Monroe County in New York. Kurlan (1994) estimated that 'developmental Tourette syndrome' occurred in at least 3% of all children and that up ...