Girolami et al. (1976) described combined deficiency of factors VII and VIII in 6 members of a family. Antigen levels were normal or near normal, suggesting that the defect was one of activation of the 2 factors. ... Girolami et al. (1976) described combined deficiency of factors VII and VIII in 6 members of a family. Antigen levels were normal or near normal, suggesting that the defect was one of activation of the 2 factors. Machin and Miller (1980) described a 16-year-old Greek male and his mother who had moderate defects of factors VII and VIII. The son presented with recurrent gastrointestinal bleeding. In each family deficiency occurred in 2 successive generations, with comparable level of factors in each. Both males and females were affected.