MAJOR AFFECTIVE DISORDER 1

General Information (adopted from Orphanet):

Synonyms, Signs: MANIC-DEPRESSIVE PSYCHOSIS
BIPOLAR AFFECTIVE DISORDER
MANIC-DEPRESSIVE PSYCHOSIS, AUTOSOMAL
BPAD
MD1
MAFD1
Number of Symptoms 5
OrphanetNr:
OMIM Id: 125480
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0100754) Mania 1 / 7739
2
(HPO:0000716) Depression 99 / 7739
3
(OMIM) Depression with mania (bipolar 1) 1 / 7739
4
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
5
(OMIM) Depression with hypomania (bipolar 2) 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Depressive disorders represent a prevalent (1 to 2%) and major illness characterized by episodes of dysphoria that are associated with somatic symptoms. It may have a manic-depressive (bipolar) or purely depressive (unipolar) course. The most characteristic features of ...
Molecular genetics OMIM - Association with the SLC6A3 Gene on Chromosome 5p15

Greenwood et al. (2001) reported evidence for an association between the DAT1 gene (SLC6A3; 126455) and bipolar disorder in a sample of 50 parent-proband trios. Using the ...