CLUSTER HEADACHE, FAMILIAL

General Information (adopted from Orphanet):

Synonyms, Signs:
Number of Symptoms 22
OrphanetNr:
OMIM Id: 119915
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000616) Miosis 11 / 7739
2
(HPO:0000508) Ptosis 459 / 7739
3
(HPO:0012531) Pain 9 / 7739
4
(HPO:0000713) Agitation 18 / 7739
5
(HPO:0000711) Restlessness 18 / 7739
6
(HPO:0003473) Fatigable weakness 39 / 7739
7
(HPO:0012199) Cluster headache 1 / 7739
8
(HPO:0000975) Hyperhidrosis 64 / 7739
9
(HPO:0000969) Edema 117 / 7739
10
(OMIM) Miosis, ipsilateral 1 / 7739
11
(OMIM) Eyelid edema, ipsilateral 1 / 7739
12
(OMIM) Rhinorrhea, ipsilateral 1 / 7739
13
(OMIM) Nasal congestion, ipsilateral 1 / 7739
14
(OMIM) Chronic subtype, headaches occur without remission for 1 year 1 / 7739
15
(OMIM) Ptosis, ipsilateral 1 / 7739
16
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
17
(OMIM) Episodic subtype, headaches occur in clusters 1 / 7739
18
(OMIM) Lacrimation, ipsilateral 1 / 7739
19
(OMIM) Headaches, severe, unilateral 1 / 7739
20
(OMIM) Forehead sweating, ipsilateral 1 / 7739
21
(OMIM) Facial sweating ipsilateral 1 / 7739
22
(OMIM) Conjunctival injection, ipsilateral 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) The classification for headache disorders of the International Headache Society (1988) listed the following criteria for cluster headache (CH): at least 5 attacks of severe unilateral orbital, supraorbital, and/or temporal pain, lasting 15 to 180 minutes, associated with ...
Clinical Description OMIM Spierings and Vincent (1992) described 3 males, an 8-year-old boy, his father and his paternal grandfather, with seemingly typical cluster headaches. The headaches responded to oxygen inhalation and to treatment with verapamil but were not prevented by propranolol ...
Molecular genetics OMIM Rainero et al. (2004) found an association between a 1246G-A polymorphism (dbSNP rs2653349) in the HCRTR2 gene (602393) and cluster headache. The frequency of the G allele was 0.96 and 0.87 among 109 patients with cluster headache and ...