COLORECTAL CANCER

General Information (adopted from Orphanet):

Synonyms, Signs: COLON CANCER
CRC
Number of Symptoms 8
OrphanetNr:
OMIM Id: 114500
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0002891) Uterine leiomyosarcoma 2 / 7739
2
(HPO:0006740) Transitional cell carcinoma of the bladder 7 / 7739
3
(HPO:0005584) Renal cell carcinoma 13 / 7739
4
(HPO:0006753) Neoplasm of the stomach 13 / 7739
5
(HPO:0006716) Hereditary nonpolyposis colorectal carcinoma 6 / 7739
6
(OMIM) APC, RAS, DCC or KRAS gene mutations 1 / 7739
7
(OMIM) Allele loss on chromosomes 5, 6, 12q, 15, 17, 18, or 22 1 / 7739
8
(OMIM) Associated endometrial carcinoma, atypical endometrial hyperplasia, uterine leiomyosarcoma, bladder transitional carcinoma, gastric, biliary and renal cell carcinoma 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Colorectal cancer is a heterogeneous disease that is common in both men and women. In addition to lifestyle and environmental risk factors, gene defects can contribute to an inherited predisposition to CRC. CRC is caused by changes in ...
Clinical Description OMIM Colon cancer is a well-known feature of familial polyposis coli. Cancer of the colon occurred in 7 members of 4 successive generations of the family reported by Kluge (1964), leading him to suggest a simple genetic basis for ...
Molecular genetics OMIM In the DNA from 1 colon and 2 lung carcinoma cell lines, Perucho et al. (1981) demonstrated the same or closely related transforming elements. By DNA-mediated gene transfer, mouse fibroblasts could be morphologically transformed and rendered tumorigenic in ...