BREAST CANCER

General Information (adopted from Orphanet):

Synonyms, Signs: BREAST CANCER, FAMILIAL BREAST CANCER, FAMILIAL MALE, INCLUDED
Number of Symptoms 1
OrphanetNr:
OMIM Id: 114480
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
Heterogeneous
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0003002) Breast carcinoma 23 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Breast cancer (referring to mammary carcinoma, not mammary sarcoma) is histopathologically and almost certainly etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement.
Clinical Description OMIM Cady (1970) described a family in which 3 sisters had bilateral breast cancer. Together with reports in the literature, this suggested to him the existence of families with a particular tendency to early-onset, bilateral breast cancer. The genetic ...
Molecular genetics OMIM - Somatic Changes

A previously reported loss of alleles at the HRAS locus, located at 11p14, in about 20% of breast cancer tumors was confirmed by Mackay et al. (1988). Comparing tumor and blood leukocyte DNA ...