BLOOD GROUP, DUFFY SYSTEM

General Information (adopted from Orphanet):

Synonyms, Signs: DUFFY BLOOD GROUP SYSTEM PLASMODIUM VIVAX, RESISTANCE TO, INCLUDED
FY
Number of Symptoms 5
OrphanetNr:
OMIM Id: 110700
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0001939) Abnormality of metabolism/homeostasis 328 / 7739
2
(HPO:0002715) Abnormality of the immune system 46 / 7739
3
(OMIM) Duffy negative blacks are more resistant to vivax malaria 1 / 7739
4
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
5
(OMIM) Duffy blood group 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) The Duffy blood group system, which consists of 4 alleles, 5 phenotypes, and 5 antigens, is important in clinical medicine because of transfusion incompatibilities and hemolytic disease of the newborn. Duffy antigens are located on DARC (613665), an ...
Clinical Description OMIM An association between sickle cell trait (603903) and Duffy-null blood group was demonstrated in Saudi Arabs (Gelpi and King, 1976). Neither linkage nor association of the usual type was the basis, but rather a protection against malaria provided ...
Molecular genetics OMIM - FYA/FYB Polymorphism

Tournamille et al. (1995) found that a single amino acid difference (G42D; 613665.001) in DARC accounts for the difference between the FYA and FYB alleles at the Duffy blood group locus. Mallinson et ...