Hofmann et al. (1984) described isolated (solitary) bladder diverticulum in males of 3 and probably 4 generations. In most patients, the diverticulum was located near the vesicoureteral junction. Moderate sclerosis of the urethral sphincter with a prominent median ... Hofmann et al. (1984) described isolated (solitary) bladder diverticulum in males of 3 and probably 4 generations. In most patients, the diverticulum was located near the vesicoureteral junction. Moderate sclerosis of the urethral sphincter with a prominent median bar of the prostate was a consistent finding. Symptoms varied from gross hematuria, diurnal frequency, infection and urinary hesitancy to only mild dysuria. One patient was entirely asymptomatic. The diverticula consisted mainly of mucosa covered only by a few strands of muscle. Bladder diverticula occur also in the Ehlers-Danlos syndrome (see 130000).