Stauffer and Merrihew (1944) reported a family segregating autosomal dominant sacroiliac arthritis, with 22 affected individuals over 4 generations. Affected individuals complained of episodes of pain beginning in the second decade of life, incapacitating in some patients, centered ... Stauffer and Merrihew (1944) reported a family segregating autosomal dominant sacroiliac arthritis, with 22 affected individuals over 4 generations. Affected individuals complained of episodes of pain beginning in the second decade of life, incapacitating in some patients, centered in the sacroiliac region, and extending down into the legs. Unspecified renal disease was reported in 6 of the 22 affected individuals, and 6 patients also reported that the attacks of sacroiliac pain were accompanied by tingling, swelling, and itching of the hands and feet. Two patients were reported to have an excess of uric acid on urinanalysis; x-rays in an affected mother and son showed no bone deformation. Stauffer and Merrihew (1944) noted that if the renal disorder was secondary to a disorder of purine metabolism, the disease in this family would be more closely allied to the arthritis of gout (see 138900) than to any other form of arthritis.