ALZHEIMER DISEASE 2

General Information (adopted from Orphanet):

Synonyms, Signs: ALZHEIMER DISEASE 2, LATE-ONSET
ALZHEIMER DISEASE ASSOCIATED WITH APOE4
AD2
Number of Symptoms 7
OrphanetNr:
OMIM Id: 104310
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000726) Dementia 131 / 7739
2
(HPO:0001300) Parkinsonism 75 / 7739
3
(HPO:0002511) Alzheimer disease 10 / 7739
4
(HPO:0002423) Long-tract signs 7 / 7739
5
(HPO:0002185) Neurofibrillary tangles 14 / 7739
6
(HPO:0003584) Late onset 10 / 7739
7
(OMIM) Presenile and senile dementia 2 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Using positron emission tomography (PET), Reiman et al. (1996) found that 11 cognitively normal subjects aged 50 to 65 years who were homozygous for the APOE4 allele had reduced glucose metabolism in the same regions of the brain ...
Molecular genetics OMIM Corder et al. (1993) found that the risk for late-onset AD increased from 20 to 90% and mean age of onset decreased from 84 to 68 years with increasing number of APOE*E4 alleles (107741.0016) in 42 families with ...
Population genetics OMIM Romas et al. (2002) found that both early-onset and late-onset familial AD occurs in Caribbean Hispanics. In contrast to sporadic AD, late-onset familial AD among Caribbean Hispanics was strongly associated with APOE4.