Onwukwe et al. (1973) described a family in which multiple members of 4 generations and by inference a fifth, in a pattern consistent with autosomal dominant inheritance (including male-to-male transmission), had persistent, asymptomatic, yellowish-white, translucent papules and plaques ... Onwukwe et al. (1973) described a family in which multiple members of 4 generations and by inference a fifth, in a pattern consistent with autosomal dominant inheritance (including male-to-male transmission), had persistent, asymptomatic, yellowish-white, translucent papules and plaques on the hands and feet, associated with fine-textured scalp hair and atopic diathesis. Histologic study of the translucent lesions showed orthohypergranulosis, acanthosis, and a relatively normal dermis. Onwukwe et al. (1973) suggested that this might be a new variant of familial punctate keratoderma. De Wit and Hulsmans (1986) observed a Suriname woman with abnormalities of palmar and plantar skin. Her father was reported to have similar changes confined to the feet. The index patient was observed to have both classical keratosis punctata palmaris et plantaris (175860) and papulotranslucent acrokeratoderma. Sracic et al. (2005) reported a 27-year-old female who developed white translucent papules bilaterally on her palms, and to a lesser extent, on her soles, at age 21 years. The palmar lesions became dramatically pronounced immediately after taking showers, and would lessen in severity after approximately 1 hour. She had fine-textured scalp hair, and her mother and brother had a history of asthma. There was no associated palmar hyperhidrosis or history of exposure to arsenic. The patient's maternal grandmother, mother, sister, and 2 half-brothers all had similar, though less severe, symptoms; her maternal grandmother, mother, and 1 half brother also had a history of Hailey-Hailey disease (BCPM; 169600).