Feder et al. (1993) described a family in which members of 3 successive generations had anterior corneal dystrophy. The onset was characterized by frequent, recurrent corneal erosions in the first decade of life. This subsided during adolescence and ... Feder et al. (1993) described a family in which members of 3 successive generations had anterior corneal dystrophy. The onset was characterized by frequent, recurrent corneal erosions in the first decade of life. This subsided during adolescence and was followed by progressively decreasing visual acuity. Slit-lamp examination revealed bilateral subepithelial opacities and haze, involving the entire cornea but most dense centrally. Light microscopy revealed a subepithelial band of eosinophilic, periodic acid-Schiff-positive, Alcian blue-positive, hyaluronidase-sensitive material present anterior to the Bowman layer. Transmission electron microscopy showed subepithelial deposits of fine fibrillar material. Immunohistochemistry showed that the abnormal material was a combination of chondroitin-4-sulfate and dermatan sulfate. The condition clinically resembled Grayson-Wilbrandt dystrophy but differed histochemically.