Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most commonly between 6 months and 4 years of age. The course is characterized by a complete recovery, usually within 1 ... Transient erythroblastopenia of childhood is a pure red cell aplasia that occurs in a previously healthy child, most commonly between 6 months and 4 years of age. The course is characterized by a complete recovery, usually within 1 to 2 months after diagnosis. In most cases no therapy is necessary, although some children may need red cell transfusion (summary by Gustavsson et al., 2002).
Seip (1982) observed transient erythroblastopenia in a brother and sister of unrelated parents. An age difference of 23 months separated the sibs. Onset was at 21 and 19 months, respectively, after an upper respiratory infection in the boy ... Seip (1982) observed transient erythroblastopenia in a brother and sister of unrelated parents. An age difference of 23 months separated the sibs. Onset was at 21 and 19 months, respectively, after an upper respiratory infection in the boy and chickenpox in the girl. Anemia without reticulocytosis was a feature. Prednisone therapy was accompanied by rapid recovery. Wranne (1970) first reported the disorder. No previous report of familial cases was known to Seip (1982). Gustavsson et al. (2002) noted that, at onset, transient erythroblastopenia of childhood may be difficult to distinguish from Diamond-Blackfan anemia (DBA; 105650), which can be caused by mutation in the gene encoding ribosomal protein S19 (RPS19; 603474) on chromosome 19q13.
To determine if TEC and DBA are allelic, Gustavsson et al. (2002) investigated the segregation of markers spanning the RPS19 gene in 7 sib pairs with TEC. No structural mutations were identified.