Criss-cross heart

General Information (adopted from Orphanet):

Synonyms, Signs: Superoinferior ventricles
Criss-cross atrioventricular relationships
Twisted atrioventricular connections
Number of Symptoms 13
OrphanetNr: 1461
OMIM Id:
ICD-10: Q24.8
UMLs:
MeSH:
MedDRA:
Snomed: 253269002

Prevalence, inheritance and age of onset:

Prevalence: 0.8 of 100 000 [Orphanet]
Inheritance: Unknown
[Orphanet]
Age of onset: Neonatal
Infancy
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Congenital heart malformation
 -Rare developmental defect during embryogenesis

Symptom Information: Sort by abundance 

1
 (HPO:0001999) Abnormal facial shape Occasional [Orphanet] 169 / 7739
2
 (HPO:0000765) Abnormality of the thorax Occasional [Orphanet] 64 / 7739
3
 (HPO:0004325) Decreased body weight Frequent [Orphanet] 492 / 7739
4
 (HPO:0000980) Pallor Frequent [Orphanet] 52 / 7739
5
 (HPO:0001063) Acrocyanosis Very frequent [Orphanet] 56 / 7739
6
 (HPO:0001629) Ventricular septal defect Frequent [Orphanet] 316 / 7739
7
 (HPO:0001646) Abnormality of the aortic valve Frequent [Orphanet] 55 / 7739
8
 (HPO:0001702) Abnormality of the tricuspid valve Frequent [Orphanet] 32 / 7739
9
 (HPO:0030680) Abnormality of cardiovascular system morphology Very frequent [Orphanet] 355 / 7739
10
 (HPO:0001633) Abnormality of the mitral valve Frequent [Orphanet] 69 / 7739
11
 (HPO:0001641) Abnormality of the pulmonary valve Frequent [Orphanet] 27 / 7739
12
 (HPO:0001669) Transposition of the great arteries Frequent [Orphanet] 36 / 7739
13
 (HPO:0002093) Respiratory insufficiency Frequent [Orphanet] 410 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: