Cloacal exstrophy
General Information (adopted from Orphanet):
Synonyms, Signs: |
OMPHALOCELE-EXSTROPHY-IMPERFORATE ANUS-SPINAL DEFECTS Omphalocele - cloacal exstrophy - imperforate anus - spinal defect OEIS complex |
Number of Symptoms | 49 |
OrphanetNr: | 93929 |
OMIM Id: |
258040
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ICD-10: |
Q64.1 |
UMLs: |
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MeSH: |
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MedDRA: |
10067424 |
Snomed: |
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Prevalence, inheritance and age of onset:
Prevalence: | 0.75 of 100 000 [Orphanet] |
Inheritance: |
Multifactorial [Orphanet] |
Age of onset: |
Neonatal Infancy [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Exstrophy-epispadias complex
-Rare abdominal surgical disease -Rare developmental defect during embryogenesis -Rare genetic disease -Rare renal disease -Rare urogenital disease Syndromic anorectal malformation -Rare abdominal surgical disease -Rare developmental defect during embryogenesis -Rare genetic disease |
Symptom Information:
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(HPO:0000125) | Pelvic kidney | 10 / 7739 | ||||
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(HPO:0000054) | Micropenis | 257 / 7739 | ||||
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(HPO:0000104) | Renal agenesis | 68 / 7739 | ||||
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(HPO:0000136) | Bifid uterus | 6 / 7739 | ||||
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(HPO:0000072) | Hydroureter | Occasional [Orphanet] | 146 / 7739 | |||
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(HPO:0000130) | Abnormality of the uterus | Occasional [Orphanet] | 86 / 7739 | |||
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(HPO:0001586) | Vesicovaginal fistula | 4 / 7739 | ||||
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(HPO:0000081) | Duplicated collecting system | 16 / 7739 | ||||
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(HPO:0008678) | Renal hypoplasia/aplasia | Occasional [Orphanet] | 127 / 7739 | |||
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(HPO:0000126) | Hydronephrosis | 119 / 7739 | ||||
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(HPO:0000039) | Epispadias | 7 / 7739 | ||||
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(HPO:0008714) | Ureterovesical stenosis | Occasional [Orphanet] | 10 / 7739 | |||
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(HPO:0000036) | Abnormality of the penis | Very frequent [Orphanet] | 8 / 7739 | |||
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(HPO:0000066) | Labial hypoplasia | 10 / 7739 | ||||
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(HPO:0000076) | Vesicoureteral reflux | Very frequent [Orphanet] | 94 / 7739 | |||
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(HPO:0000028) | Cryptorchidism | 347 / 7739 | ||||
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(HPO:0000062) | Ambiguous genitalia | 74 / 7739 | ||||
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(HPO:0010475) | Cloacal exstrophy | 2 / 7739 | ||||
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(HPO:0100542) | Abnormal localization of kidney | Occasional [Orphanet] | 64 / 7739 | |||
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(HPO:0000143) | Rectovaginal fistula | 18 / 7739 | ||||
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(HPO:0002991) | Abnormality of the fibula | Frequent [Orphanet] | 49 / 7739 | |||
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(HPO:0002937) | Hemivertebrae | 41 / 7739 | ||||
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(HPO:0010305) | Absence of the sacrum | 17 / 7739 | ||||
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(HPO:0001385) | Hip dysplasia | Frequent [Orphanet] | 242 / 7739 | |||
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(HPO:0008490) | Sacral segmentation defect | 2 / 7739 | ||||
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(HPO:0011301) | Absent foot | Frequent [Orphanet] | 4 / 7739 | |||
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(HPO:0000878) | 11 pairs of ribs | 19 / 7739 | ||||
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(HPO:0002475) | Myelomeningocele | Frequent [Orphanet] | 29 / 7739 | |||
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(HPO:0001762) | Talipes equinovarus | Frequent [Orphanet] | 309 / 7739 | |||
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(HPO:0002414) | Spina bifida | Frequent [Orphanet] | 47 / 7739 | |||
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(HPO:0001374) | Congenital hip dislocation | 51 / 7739 | ||||
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(HPO:0002992) | Abnormality of the tibia | Frequent [Orphanet] | 51 / 7739 | |||
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(HPO:0003422) | Vertebral segmentation defect | Frequent [Orphanet] | 95 / 7739 | |||
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(HPO:0100668) | Intestinal duplication | Frequent [Orphanet] | 2 / 7739 | |||
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(HPO:0002566) | Intestinal malrotation | Frequent [Orphanet] | 89 / 7739 | |||
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(HPO:0100548) | Exstrophy | Very frequent [Orphanet] | 4 / 7739 | |||
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(HPO:0001539) | Omphalocele | Very frequent [Orphanet] | 102 / 7739 | |||
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(HPO:0002244) | Abnormality of the small intestine | Frequent [Orphanet] | 12 / 7739 | |||
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(HPO:0001545) | Anteriorly placed anus | 55 / 7739 | ||||
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(HPO:0005223) | Duplicated colon | 2 / 7739 | ||||
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(HPO:0002023) | Anal atresia | Frequent [Orphanet] | 135 / 7739 | |||
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(HPO:0002144) | Tethered cord | 8 / 7739 | ||||
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(OMIM) | Abnormal or absent scrotum | 1 / 7739 | ||||
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(HPO:0000238) | Hydrocephalus | 278 / 7739 | ||||
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(OMIM) | Widely separated labioscrotal folds | 1 / 7739 | ||||
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(HPO:0002308) | Arnold-Chiari malformation | 42 / 7739 | ||||
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(OMIM) | Lipomyelocystoceles | 1 / 7739 | ||||
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(OMIM) | Symphysis pubis diastasis | 1 / 7739 | ||||
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(HPO:0012815) | Hypoplastic female external genitalia | Very frequent [Orphanet] | 36 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Clinical Description OMIM |
Carey et al. (1978) gave the name OEIS complex to a combination of defects comprising omphalocele, exstrophy of the cloaca, imperforate anus, and spinal defects. This rare complex is thought to represent the most severe end of a ... |
Population genetics OMIM |
Feldkamp et al. (2011) performed an epidemiologic study of cloacal exstrophy to describe the prevalence, associated anomalies, and maternal characteristics. Feldkamp et al. (2011) used data from the International Clearinghouse Birth Defects Surveillance and Research submitted from 18 ... |