Tubulointerstitial nephritis and uveitis syndrome

General Information (adopted from Orphanet):

Synonyms, Signs: ATIN, INCLUDED
TINU ACUTE TUBULOINTERSTITIAL NEPHRITIS, INCLUDED
Acute tubulointerstitial nephritis and uveitis syndrome
TINU syndrome
Number of Symptoms 13
OrphanetNr: 91500
OMIM Id: 607665
ICD-10: N10
UMLs: C1639520
C2609298
MeSH: C536922
MedDRA: 10069034
10069039
Snomed: 418839003

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Sporadic
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: Rare renal tubular disease
 -Rare renal disease
Systemic diseases with anterior uveitis
 -Rare eye disease

Symptom Information: Sort by abundance 

1
 (HPO:0000099) Glomerulonephritis 13 / 7739
2
 (HPO:0004713) Reversible renal failure 2 / 7739
3
 (HPO:0004729) Acute tubulointerstitial nephritis 1 / 7739
4
 (HPO:0000153) Abnormality of the mouth 60 / 7739
5
 (HPO:0012122) Anterior uveitis 4 / 7739
6
 (HPO:0012121) Panuveitis rare [HPO:skoehler] 1 / 7739
7
 (HPO:0000554) Uveitis 10 / 7739
8
 (HPO:0012220) Non-caseating epithelioid cell granulomatosis 3 / 7739
9
 (HPO:0003259) Elevated serum creatinine 31 / 7739
10
 (HPO:0012224) Circulating immune complexes 1 / 7739
11
 (HPO:0003745) Sporadic 131 / 7739
12
 (OMIM) Sialoadenitis, mild chronic (in some cases) 1 / 7739
13
 (OMIM) Non-caseating granulomas (bone marrow and lymph nodes) 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Dobrin et al. (1975) described 2 adolescent female patients with tubulointerstitial nephritis and uveitis (TINU); noncaseating granulomas were present in bone marrow in both and in lymph nodes in one.

Gianviti et al. (1994) reported monozygotic ...