WAGR syndrome
General Information (adopted from Orphanet):
Synonyms, Signs: |
Wilms tumor - aniridia - genitourinary anomalies - intellectual deficit Deletion 11p13 Monosomy 11p13 |
Number of Symptoms | 31 |
OrphanetNr: | 893 |
OMIM Id: |
194072
612469 |
ICD-10: |
Q87.8 |
UMLs: |
C0206115 C2931803 |
MeSH: |
C538295 D017624 |
MedDRA: |
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Snomed: |
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Prevalence, inheritance and age of onset:
Prevalence: | No data available. |
Inheritance: |
Autosomal dominant [Orphanet] |
Age of onset: |
Neonatal [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Inherited renal cell cancer-predisposing syndrome
-Rare genetic disease -Rare oncologic disease -Rare renal disease Partial deletion of the short arm of chromosome 11 -Rare developmental defect during embryogenesis -Rare genetic disease Polymalformative genetic syndrome with increased risk of developing cancer -Rare genetic disease -Rare oncologic disease Rare disease with glaucoma as a major feature -Rare eye disease -Rare genetic disease Syndrome with 46,XY disorder of sex development -Rare developmental defect during embryogenesis -Rare endocrine disease -Rare genetic disease -Rare urogenital disease Syndrome with disorder of sex development of gynecological interest -Rare genetic disease -Rare gynecologic or obstetric disease Syndromic aniridia -Rare developmental defect during embryogenesis -Rare eye disease -Rare genetic disease Syndromic cataract -Rare eye disease -Rare genetic disease Syndromic developmental defect of the eye -Rare developmental defect during embryogenesis -Rare eye disease -Rare genetic disease Syndromic obesity -Rare developmental defect during embryogenesis -Rare endocrine disease -Rare genetic disease Syndromic renal or urinary tract malformation -Rare developmental defect during embryogenesis -Rare genetic disease -Rare renal disease |
Symptom Information:
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(HPO:0000130) | Abnormality of the uterus | occasional [HPO] | 86 / 7739 | |||
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(HPO:0000028) | Cryptorchidism | typical [HPO] | 347 / 7739 | |||
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(HPO:0000083) | Renal insufficiency | 10/46 [HPO] | 232 / 7739 | |||
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(HPO:0000142) | Abnormality of the vagina | frequent [HPO] | 24 / 7739 | |||
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(HPO:0000062) | Ambiguous genitalia | Occasional [Orphanet] | 74 / 7739 | |||
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(HPO:0000035) | Abnormality of the testis | Frequent [Orphanet] | 296 / 7739 | |||
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(HPO:0002667) | Nephroblastoma | typical [HPO] | 30 / 7739 | |||
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(HPO:0000112) | Nephropathy | 40% [HPO] | 92 / 7739 | |||
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(HPO:0010464) | Streak ovary | frequent [HPO] | 8 / 7739 | |||
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(HPO:0000150) | Gonadoblastoma | occasional [HPO] | 8 / 7739 | |||
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(HPO:0000047) | Hypospadias | Frequent [Orphanet] typical [HPO] | 250 / 7739 | |||
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(HPO:0000277) | Abnormality of the mandible | Frequent [Orphanet] | 394 / 7739 | |||
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(HPO:0000159) | Abnormality of the lip | Frequent [Orphanet] | 33 / 7739 | |||
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(HPO:0000252) | Microcephaly | Frequent [Orphanet] | 832 / 7739 | |||
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(HPO:0000508) | Ptosis | Frequent [Orphanet] | 459 / 7739 | |||
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(HPO:0000526) | Aniridia | hallmark [HPO] | 12 / 7739 | |||
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(HPO:0000518) | Cataract | Frequent [Orphanet] | 454 / 7739 | |||
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(HPO:0000572) | Visual loss | Frequent [Orphanet] | 272 / 7739 | |||
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(HPO:0008053) | Aplasia/Hypoplasia of the iris | Very frequent [Orphanet] | 38 / 7739 | |||
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(HPO:0000501) | Glaucoma | Occasional [Orphanet] | 180 / 7739 | |||
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(HPO:0000639) | Nystagmus | Frequent [Orphanet] | 555 / 7739 | |||
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(HPO:0000598) | Abnormality of the ear | Frequent [Orphanet] | 98 / 7739 | |||
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(HPO:0001249) | Intellectual disability | typical [HPO] | 1089 / 7739 | |||
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(HPO:0002650) | Scoliosis | Occasional [Orphanet] | 705 / 7739 | |||
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(HPO:0004299) | Hernia of the abdominal wall | Occasional [Orphanet] | 176 / 7739 | |||
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(HPO:0001513) | Obesity | Occasional [Orphanet] occasional [HPO] | 172 / 7739 | |||
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(HPO:0004322) | Short stature | Frequent [Orphanet] | 1232 / 7739 | |||
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(HPO:0000006) | Autosomal dominant inheritance | 2518 / 7739 | ||||
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(HPO:0012758) | Neurodevelopmental delay | Very frequent [Orphanet] | 949 / 7739 | |||
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(HPO:0001466) | Contiguous gene syndrome | 8 / 7739 | ||||
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(HPO:0001428) | Somatic mutation | 100 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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