In a Japanese kindred, Yamamoto et al. (1966) found tremor and/or anosmia or hyposmia in 14 persons. They suggested that the 2 traits are independent dominants. Their findings may be equally consistent with the pleiotropic and variable effects ... In a Japanese kindred, Yamamoto et al. (1966) found tremor and/or anosmia or hyposmia in 14 persons. They suggested that the 2 traits are independent dominants. Their findings may be equally consistent with the pleiotropic and variable effects of a single gene. In the Faroe Islands, Lygonis (1969) found a large kindred in which 9 males and 19 females in 4 generations had anosmia with no other abnormality. Singh et al. (1970) observed anosmia in 6 males in 3 consecutive generations. One male who transmitted the trait had only partial anosmia. Assouline et al. (1998) reported 2 patients with isolated congenital anosmia, a 15.5-year-old girl and an 11-year-old boy. In both patients, bilateral aplasia of the olfactory bulbs was demonstrated by cranial magnetic resonance imaging. One of the patients of Hockaday (1966) with anosmia-hypogonadism had father and a brother with anosmia alone. Some family members of patients with Kallmann syndrome (see Pitteloud et al., 2006 and 147950) have been found to have isolated congenital anosmia.