Atrial tachyarrhythmia with short PR interval
General Information (adopted from Orphanet):
| Synonyms, Signs: |
Lown-Ganong-Levine syndrome |
| Number of Symptoms | 16 |
| OrphanetNr: | 844 |
| OMIM Id: |
108950
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| ICD-10: |
I45.6 |
| UMLs: |
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| MeSH: |
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| MedDRA: |
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| Snomed: |
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Prevalence, inheritance and age of onset:
| Prevalence: | < 0.1 of 100 000 |
| Inheritance: |
Autosomal dominant 836114 [IBIS] |
| Age of onset: |
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Disease classification (adopted from Orphanet):
| Parent Diseases: |
Genetic cardiac rhythm disease
-Rare cardiac disease -Rare genetic disease |
Comment:
| Atrial tachyarrhythmia with short PR interval or Lown-Ganong-Levine syndrome is most commonly seen in young to middle-aged women. It is characterized by short PR intervals, paroxysmal supraventricular tachycardia and normal QRS complex (PMID:14662232). |
Symptom Information:
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(HPO:0008872) | Feeding difficulties in infancy | 19859765 | IBIS | 153 / 7739 | ||
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(HPO:0002094) | Dyspnea | 14662232 | IBIS | 132 / 7739 | ||
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(HPO:0002098) | Respiratory distress | 19859765 | IBIS | 75 / 7739 | ||
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(MedDRA:10049694) | Left ventricular dysfunction | 836114 | IBIS | 10 / 7739 | ||
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(HPO:0005165) | Shortened PR interval | Very frequent [IBIS] | 14662232 | IBIS | 9 / 7739 | |
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(HPO:0001962) | Palpitations | Frequent [IBIS] | 14662232 | IBIS | 62 / 7739 | |
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(HPO:0005115) | Supraventricular arrhythmia | 14662232 | IBIS | 13 / 7739 | ||
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(HPO:0004757) | Paroxysmal atrial fibrillation | Very frequent [IBIS] | 14662232 | IBIS | 16 / 7739 | |
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(HPO:0004749) | Atrial flutter | Frequent [IBIS] | 14662232 | IBIS | 20 / 7739 | |
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(HPO:0011687) | AV nodal tachycardia | Occasional [IBIS] | 14662232 | IBIS | 3 / 7739 | |
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(HPO:0011717) | AV nodal reentry tachycardia | 14662232 | IBIS | 2 / 7739 | ||
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(HPO:0004763) | Paroxysmal supraventricular tachycardia | 14662232 | IBIS | 10 / 7739 | ||
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(HPO:0006671) | Paroxysmal atrial tachycardia | Frequent [IBIS] | 14662232 | IBIS | 4 / 7739 | |
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(HPO:0011701) | Multifocal atrial tachycardia | Occasional [IBIS] | 14662232 | IBIS | 7 / 7739 | |
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(HPO:0001649) | Tachycardia | 14662232 | IBIS | 53 / 7739 | ||
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(HPO:0100749) | Chest pain | 14662232 | IBIS | 92 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
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