Infant acute respiratory distress syndrome

General Information (adopted from Orphanet):

Synonyms, Signs: RDS OF PREMATURITY
HYALINE MEMBRANE DISEASE, FORMERLY
Hyaline membrane disease
Infant ARDS
Neonatal respiratory distress syndrome
Infant respiratory distress syndrome
Number of Symptoms 13
OrphanetNr: 70587
OMIM Id: 267450
ICD-10: P22.0
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: > 10 of 100 000 [Orphanet]
Inheritance: Not applicable
[Orphanet]
Age of onset: Neonatal
Infancy
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Primary interstitial lung disease specific to childhood due to alveolar structure disorder
 -Rare respiratory disease

Symptom Information: Sort by abundance 

1
(HPO:0001622) Premature birth 100 / 7739
2
(HPO:0005521) Disseminated intravascular coagulation 5 / 7739
3
(HPO:0100598) Pulmonary edema 17 / 7739
4
(HPO:0000969) Edema 117 / 7739
5
(HPO:0002094) Dyspnea 132 / 7739
6
(HPO:0002643) Neonatal respiratory distress 22 / 7739
7
(HPO:0002789) Tachypnea 48 / 7739
8
(HPO:0100750) Atelectasis 17 / 7739
9
(OMIM) Fibrin-rich alveolar deposits, 'hyaline membranes' 1 / 7739
10
(OMIM) Premature delivery, less than 37 weeks' gestation 1 / 7739
11
(OMIM) Respiratory insufficiency, neonatal 1 / 7739
12
(OMIM) Chest radiographs show diffuse reticulogranular pattern 1 / 7739
13
(OMIM) Decreased surfactant 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Respiratory distress syndrome in the newborn is the main cause of mortality and morbidity in premature infants. RDS is characterized by deficient gas exchange that is caused by diffuse atelectasis and high-permeability lung edema that results in fibrin-rich ...
Molecular genetics OMIM Using a candidate gene approach, Ramet et al. (2000) studied the association between the surfactant protein A1 gene (SFTPA1; 178630) and RDS in Finland. They matched 88 infants with RDS and 88 control infants for degree of prematurity, ...