Tako-Tsubo cardiomyopathy

General Information (adopted from Orphanet):

Synonyms, Signs: Ballooning cardiomyopathy
Tako-tsubo syndrome
Takotsubo cardiomyopathy
Takotsubo syndrome
Apical ballooning syndrome
Ampulla cardiomyopathy
Transient left ventricular apical ballooning syndrome
Stress cardiomyopathy
Number of Symptoms 30
OrphanetNr: 66529
OMIM Id:
ICD-10: I42.8
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: < 20 of 100 000 - PMID: 22795284 [IBIS]
Inheritance:
Age of onset: Adult
- PMID: 22795284 [IBIS]

Disease classification (adopted from Orphanet):

Parent Diseases: Unclassified cardiomyopathy
 -Rare cardiac disease

Comment:

Takotsubo cardiomyopathy (TTC) is characterized by transient left ventricular apical ballooning with the absence of coronary occlusion, which typically occurs in older women after emotional or physical stress (PMID:26896623).

Symptom Information: Sort by abundance 

1
 (HPO:0001649) Tachycardia 19082409 IBIS 53 / 7739
2
 (HPO:0002375) Hypokinesia 18378018 IBIS 25 / 7739
3
 (HPO:0002666) Pheochromocytoma 22441003 IBIS 9 / 7739
4
 (HPO:0002304) Akinesia 19082409 IBIS 18 / 7739
5
 (HPO:0100660) Dyskinesia 19800075 IBIS 19 / 7739
6
 (HPO:0002487) Hyperkinesis 19938049 IBIS 7 / 7739
7
 (HPO:0100749) Chest pain 18955900 IBIS 92 / 7739
8
 (HPO:0011675) Arrhythmia 19938049 IBIS 226 / 7739
9
 (HPO:0002615) Hypotension 19254634 IBIS 52 / 7739
10
 (HPO:0011665) Takotsubo cardiomyopathy 22108927 IBIS 1 / 7739
11
 (HPO:0001677) Coronary artery disease 18045705 IBIS 58 / 7739
12
 (HPO:0000822) Hypertension 19082409 IBIS 224 / 7739
13
 (HPO:0001663) Ventricular fibrillation 15986008 IBIS 35 / 7739
14
 (HPO:0001279) Syncope 15986008 IBIS 94 / 7739
15
 (HPO:0001658) Myocardial infarction 18955900 IBIS 30 / 7739
16
 (HPO:0001653) Mitral regurgitation 18045705 IBIS 64 / 7739
17
 (HPO:0001645) Sudden cardiac death 17692953 IBIS 84 / 7739
18
 (HPO:0001635) Congestive heart failure 19938049 IBIS 232 / 7739
19
 (HPO:0001297) Stroke 18718684 IBIS 44 / 7739
20
 (HPO:0002138) Subarachnoid hemorrhage 19328564 IBIS 9 / 7739
21
 (HPO:0005145) Coronary artery stenosis 18955900 IBIS 5 / 7739
22
 (HPO:0001664) Torsade de pointes 19075523 IBIS 15 / 7739
23
 (HPO:0001711) Abnormality of the left ventricle 22073853 IBIS 22 / 7739
24
 (HPO:0001962) Palpitations 20739768 IBIS 62 / 7739
25
 (HPO:0001695) Cardiac arrest 19082409 IBIS 87 / 7739
26
 (HPO:0005162) Left ventricular failure 19906451 IBIS 18 / 7739
27
 (HPO:0005184) Prolonged QTc interval 19075523 IBIS 5 / 7739
28
 (HPO:0100598) Pulmonary edema 20534335 IBIS 17 / 7739
29
 (HPO:0000969) Edema 19906451 IBIS 117 / 7739
30
 (HPO:0002094) Dyspnea 18724037 IBIS 132 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: