Yellow nail syndrome
General Information (adopted from Orphanet):
| Synonyms, Signs: |
LYMPHEDEMA AND YELLOW NAILS YNS Lymphedema with yellow nails |
| Number of Symptoms | 23 |
| OrphanetNr: | 662 |
| OMIM Id: |
153300
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| ICD-10: |
L60.5 |
| UMLs: |
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| MeSH: |
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| MedDRA: |
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| Snomed: |
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Prevalence, inheritance and age of onset:
| Prevalence: | No data available. |
| Inheritance: |
Autosomal dominant inheritance [Omim] |
| Age of onset: |
Adult [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Primary interstitial lung disease specific to childhood due to alveolar vascular disorder
-Rare respiratory disease Syndromic lymphedema -Rare circulatory system disease -Rare developmental defect during embryogenesis -Rare genetic disease -Rare skin disease Syndromic nail anomaly -Rare genetic disease -Rare skin disease |
Symptom Information:
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(HPO:0000246) | Sinusitis | Frequent [Orphanet] | 73 / 7739 | |||
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(HPO:0008383) | Slow-growing nails | 2 / 7739 | ||||
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(HPO:0008388) | Abnormality of the toenails | Very frequent [Orphanet] | 28 / 7739 | |||
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(HPO:0001231) | Abnormality of the fingernails | Very frequent [Orphanet] | 116 / 7739 | |||
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(HPO:0011367) | Yellow nails | 2 / 7739 | ||||
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(HPO:0001805) | Thick nail | Very frequent [Orphanet] | 96 / 7739 | |||
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(HPO:0001820) | Leukonychia | Very frequent [Orphanet] | 18 / 7739 | |||
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(HPO:0003550) | Predominantly lower limb lymphedema | 5 / 7739 | ||||
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(HPO:0001004) | Lymphedema | Very frequent [Orphanet] | 62 / 7739 | |||
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(HPO:0002093) | Respiratory insufficiency | Frequent [Orphanet] | 410 / 7739 | |||
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(HPO:0002205) | Recurrent respiratory infections | Frequent [Orphanet] | 254 / 7739 | |||
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(HPO:0002103) | Abnormality of the pleura | Very frequent [Orphanet] | 58 / 7739 | |||
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(HPO:0002110) | Bronchiectasis | Very frequent [Orphanet] | 73 / 7739 | |||
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(HPO:0002664) | Neoplasm | Occasional [Orphanet] | 111 / 7739 | |||
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(HPO:0100763) | Abnormality of the lymphatic system | Very frequent [Orphanet] | 18 / 7739 | |||
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(HPO:0010978) | Abnormality of immune system physiology | Occasional [Orphanet] | 148 / 7739 | |||
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(HPO:0003759) | Hypoplasia of lymphatic vessels | 4 / 7739 | ||||
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(HPO:0003011) | Abnormality of the musculature | 47 / 7739 | ||||
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(HPO:0000006) | Autosomal dominant inheritance | 2518 / 7739 | ||||
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(OMIM) | Lymphography shows hypoplasia of the lymphatic vessels | 1 / 7739 | ||||
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([DEL]MedDRA:10011224) | Cough | Frequent [Orphanet] | 70 / 7739 | |||
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(OMIM) | Lymphedema, predominantly in the lower limbs | 4 / 7739 | ||||
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(OMIM) | Excessively curved nails | 1 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
| Description: (OMIM) |
Yellow nail syndrome (YNS) is classically considered to comprise a clinical triad of yellow nails, lymphedema, and respiratory tract involvement. Two of these symptoms are required for the diagnosis, since the complete triad is only observed in about ... |
| Clinical Description OMIM |
Samman and White (1964) delineated the yellow nail syndrome, reporting 13 cases. The nails are typically slow growing and excessively curved, with a yellowish discoloration, and frequently show ridging due to interrupted growth. Onycholysis can occur in one ... |
| Molecular genetics OMIM |
Finegold et al. (2001) identified a mutation in the FOXC2 gene (602402.0007) in affected members of a family with lymphedema-distichiasis syndrome (153400). None of these patients were reported as having yellow nails. However, the same mutation was found ... |