Gastric cancer

General Information (adopted from Orphanet):

Synonyms, Signs: Stomach cancer
Number of Symptoms 2
OrphanetNr: 63443
OMIM Id: 613659
ICD-10: C16
UMLs:
MeSH:
MedDRA: 10017758
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: 49.2 of 100 000 [Orphanet]
Inheritance: Multifactorial
Not applicable
[Orphanet]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Gastro-esophageal tumor
 -Rare gastroenterologic disease
 -Rare oncologic disease

Symptom Information: Sort by abundance 

1
(HPO:0012126) Stomach cancer 3 / 7739
2
(HPO:0001428) Somatic mutation 100 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer.

Gastric cancer is a manifestation of a ...

Clinical Description OMIM Scott et al. (1990) described a family in which 2 of 4 sibs under the age of 40 years presented with gastric cancer. A third sib had antrectomy for gastric dysplasia, and a fourth, aged 36, had extensive ...
Molecular genetics OMIM - Germline Mutations in Cancer Predisposition Syndromes

Carriers of germline mutations in mismatch repair genes (see, e.g., MLH1, 120436) have a 4-fold increased risk of gastric cancer in addition to the high risk of colorectal cancer ...

Population genetics OMIM Despite a declining incidence (Howson et al., 1986), gastric cancer is a major cause of cancer death worldwide. Gonzalez et al. (2002) observed that gastric cancer constitutes the second most frequent cancer in the world and the fourth ...