Large congenital melanocytic nevus

General Information (adopted from Orphanet):

Synonyms, Signs: GPHN
GMN
GCPN
LCMN
GHPN
Giant pigmented hairy nevus
Giant congenital melanocytic nevus
Congenital pigmented nevus
Number of Symptoms 31
OrphanetNr: 626
OMIM Id: 137550
ICD-10: D22
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: 2 of 100 000 [Orphanet]
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset: Neonatal
Infancy
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Genetic skin tumor
 -Rare genetic disease
Rare nevus
 -Rare oncologic disease
 -Rare skin disease

Symptom Information: Sort by abundance 

1
(HPO:0010759) Prominence of the premaxilla 5 / 7739
2
(HPO:0000418) Narrow nasal ridge 15 / 7739
3
(HPO:0002002) Deep philtrum 42 / 7739
4
(HPO:0000311) Round face 104 / 7739
5
(HPO:0000293) Full cheeks 85 / 7739
6
(HPO:0011220) Prominent forehead 137 / 7739
7
(HPO:0003196) Short nose 264 / 7739
8
(HPO:0001965) Abnormality of the scalp Very frequent [Orphanet] 10 / 7739
9
(HPO:0000337) Broad forehead 116 / 7739
10
(HPO:0000194) Open mouth 70 / 7739
11
(HPO:0000232) Everted lower lip vermilion 90 / 7739
12
(HPO:0000343) Long philtrum 262 / 7739
13
(HPO:0000455) Broad nasal tip 67 / 7739
14
(HPO:0000629) Periorbital fullness 13 / 7739
15
(HPO:0001250) Seizures Occasional [Orphanet] 1245 / 7739
16
(HPO:0008069) Neoplasm of the skin Occasional [Orphanet] 84 / 7739
17
(HPO:0000989) Pruritus Occasional [Orphanet] 111 / 7739
18
(HPO:0005600) Congenital giant melanocytic nevus 1 / 7739
19
(HPO:0001031) Subcutaneous lipoma Occasional [Orphanet] 112 / 7739
20
(HPO:0012056) Cutaneous melanoma 10 / 7739
21
(HPO:0001000) Abnormality of skin pigmentation Very frequent [Orphanet] 105 / 7739
22
(HPO:0011362) Abnormal hair quantity Frequent [Orphanet] 92 / 7739
23
(HPO:0001052) Nevus flammeus Very frequent [Orphanet] 88 / 7739
24
(HPO:0001053) Hypopigmented skin patches Occasional [Orphanet] 80 / 7739
25
(HPO:0002664) Neoplasm Frequent [Orphanet] 111 / 7739
26
(HPO:0002861) Melanoma Occasional [Orphanet] 18 / 7739
27
(HPO:0100242) Sarcoma Occasional [Orphanet] 27 / 7739
28
(HPO:0000238) Hydrocephalus Occasional [Orphanet] 278 / 7739
29
(HPO:0030448) Soft tissue sarcoma Occasional [Orphanet] 18 / 7739
30
(OMIM) Giant pigmented hairy nevus, often in lumbosacral distribution 1 / 7739
31
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Giant pigmented hairy nevus (GHPN) is a congenital melanocytic lesion, which despite its name may not be hairy. These nevi are significant because of the risk of malignant transformation (summary by Ho et al., 1999).
Clinical Description OMIM Hecht et al. (1981) reported 2 first-cousin infants, a boy and a girl, respectively, who were born with giant pigmented hairy nevus of the scalp. The diameter of the nevi in each child approximated half of the scalp ...
Population genetics OMIM The frequency of occurrence of congenital giant pigmented hairy nevus larger than 20 cm in diameter in pediatric patients has been estimated to be 1 in 4,150. Data on possible malignant transformation of these lesions into a melanoma ...