Muckle-Wells syndrome
General Information (adopted from Orphanet):
Synonyms, Signs: |
CRYOPYRIN-ASSOCIATED PERIODIC SYNDROME 2 URTICARIA-DEAFNESS-AMYLOIDOSIS SYNDROME UDA SYNDROME CAPS2 MWS Urticaria - deafness - amyloidosis |
Number of Symptoms | 59 |
OrphanetNr: | 575 |
OMIM Id: |
191900
|
ICD-10: |
E85.0 L50.8 |
UMLs: |
C0268390 |
MeSH: |
|
MedDRA: |
10064569 |
Snomed: |
15123008 |
Prevalence, inheritance and age of onset:
Prevalence: | No data available. |
Inheritance: |
Autosomal dominant [Orphanet] |
Age of onset: |
Neonatal Infancy Childhood [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Cryopyrin-associated periodic syndrome
-Rare genetic disease -Rare immune disease -Rare skin disease -Rare systemic or rheumatologic disease Secondary glomerular disease -Rare renal disease |
Symptom Information:
|
(HPO:0000100) | Nephrotic syndrome | Frequent [Orphanet] | 83 / 7739 | |||
|
(HPO:0001917) | Renal amyloidosis | 8 / 7739 | ||||
|
(HPO:0000083) | Renal insufficiency | 232 / 7739 | ||||
|
(HPO:0000112) | Nephropathy | Frequent [Orphanet] | 92 / 7739 | |||
|
(HPO:0002705) | High, narrow palate | Occasional [Orphanet] | 308 / 7739 | |||
|
(HPO:0011107) | Recurrent aphthous stomatitis | 13 / 7739 | ||||
|
(HPO:0000445) | Wide nose | Occasional [Orphanet] | 190 / 7739 | |||
|
(HPO:0000256) | Macrocephaly | Occasional [Orphanet] | 298 / 7739 | |||
|
(HPO:0011830) | Abnormality of oral mucosa | Occasional [Orphanet] | 47 / 7739 | |||
|
(HPO:0100533) | Inflammatory abnormality of the eye | Very frequent [Orphanet] | 70 / 7739 | |||
|
(HPO:0000501) | Glaucoma | Occasional [Orphanet] | 180 / 7739 | |||
|
(HPO:0000509) | Conjunctivitis | 47 / 7739 | ||||
|
(HPO:0000407) | Sensorineural hearing impairment | Very frequent [Orphanet] | 524 / 7739 | |||
|
(HPO:0000408) | Progressive sensorineural hearing impairment | 28 / 7739 | ||||
|
(HPO:0000365) | Hearing impairment | 539 / 7739 | ||||
|
(HPO:0006824) | Cranial nerve paralysis | Very frequent [Orphanet] | 81 / 7739 | |||
|
(HPO:0009830) | Peripheral neuropathy | Occasional [Orphanet] | 206 / 7739 | |||
|
(HPO:0008373) | Puberty and gonadal disorders | Occasional [Orphanet] | 156 / 7739 | |||
|
(HPO:0001761) | Pes cavus | Occasional [Orphanet] | 225 / 7739 | |||
|
(HPO:0002829) | Arthralgia | 79 / 7739 | ||||
|
(HPO:0100490) | Camptodactyly of finger | Occasional [Orphanet] | 212 / 7739 | |||
|
(HPO:0100769) | Synovitis | Very frequent [Orphanet] | 86 / 7739 | |||
|
(HPO:0001769) | Broad foot | Very frequent [Orphanet] | 31 / 7739 | |||
|
(HPO:0005059) | Arthralgia/arthritis | Very frequent [Orphanet] | 141 / 7739 | |||
|
(HPO:0001744) | Splenomegaly | Very frequent [Orphanet] | 337 / 7739 | |||
|
(HPO:0004299) | Hernia of the abdominal wall | Occasional [Orphanet] | 176 / 7739 | |||
|
(HPO:0002027) | Abdominal pain | Frequent [Orphanet] | 184 / 7739 | |||
|
(HPO:0002240) | Hepatomegaly | Very frequent [Orphanet] | 467 / 7739 | |||
|
(HPO:0004322) | Short stature | Occasional [Orphanet] | 1232 / 7739 | |||
|
(HPO:0000951) | Abnormality of the skin | 147 / 7739 | ||||
|
(HPO:0008064) | Ichthyosis | Occasional [Orphanet] | 108 / 7739 | |||
|
(HPO:0001025) | Urticaria | Frequent [Orphanet] | 73 / 7739 | |||
|
(HPO:0012089) | Arteritis | Occasional [Orphanet] | 40 / 7739 | |||
|
(HPO:0001974) | Leukocytosis | 33 / 7739 | ||||
|
(HPO:0001903) | Anemia | Occasional [Orphanet] | 289 / 7739 | |||
|
(HPO:0001954) | Episodic fever | 27 / 7739 | ||||
|
(HPO:0011227) | Elevated C-reactive protein level | Frequent [Orphanet] | 55 / 7739 | |||
|
(HPO:0001939) | Abnormality of metabolism/homeostasis | Frequent [Orphanet] | 328 / 7739 | |||
|
(HPO:0003565) | Elevated erythrocyte sedimentation rate | 31 / 7739 | ||||
|
(HPO:0001945) | Fever | Occasional [Orphanet] | 218 / 7739 | |||
|
(HPO:0001608) | Abnormality of the voice | Occasional [Orphanet] | 126 / 7739 | |||
|
(HPO:0002091) | Restrictive ventilatory defect | Occasional [Orphanet] | 46 / 7739 | |||
|
(HPO:0003202) | Skeletal muscle atrophy | Occasional [Orphanet] | 281 / 7739 | |||
|
(HPO:0003326) | Myalgia | Occasional [Orphanet] | 143 / 7739 | |||
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(OMIM) | Rash may or may not be pruritic | 2 / 7739 | ||||
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(OMIM) | Episodic myalgia | 3 / 7739 | ||||
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(OMIM) | Sensorineural deafness, progressive, late-onset | 1 / 7739 | ||||
|
(OMIM) | Maculopapular rash, episodic | 2 / 7739 | ||||
|
(HPO:0003593) | Infantile onset | 249 / 7739 | ||||
|
(OMIM) | Conjunctivitis, episodic | 1 / 7739 | ||||
|
(OMIM) | Lower extremity pain | 1 / 7739 | ||||
|
(HPO:0012795) | Abnormality of the optic disc | Occasional [Orphanet] | 187 / 7739 | |||
|
(OMIM) | Increased erythrocyte sedimentation rate, episodic | 1 / 7739 | ||||
|
(OMIM) | Renal amyloidosis, late-onset | 2 / 7739 | ||||
|
(OMIM) | Arthralgia, episodic | 2 / 7739 | ||||
|
(OMIM) | Increased IL6, episodic | 1 / 7739 | ||||
|
(HPO:0000006) | Autosomal dominant inheritance | 2518 / 7739 | ||||
|
(OMIM) | Stiff skin | Very frequent [Orphanet] | 31 / 7739 | |||
|
(OMIM) | Polymorphonuclear leukocytosis, episodic | 2 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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Additional Information:
Description: (OMIM) |
Muckle-Wells syndrome (MWS) is characterized by episodic skin rash, arthralgias, and fever associated with late-onset sensorineural deafness and renal amyloidosis (Dode et al., 2002). See also familial cold-induced autoinflammatory syndrome-1 (FCAS1, CAPS1; 120100), an allelic disorder ... |
Clinical Description OMIM |
Muckle and Wells (1962) described a family in which urticaria, progressive perceptive deafness, and amyloidosis were combined in a dominantly inherited syndrome. Five generations were affected. Autopsy in 2 patients showed absent organ of Corti, atrophy of the ... |
Molecular genetics OMIM |
In a family with Muckle-Wells syndrome, Hoffman et al. (2001) found a mutation in the NLRP3 gene (606416.0004). Hoffman et al. (2001) also found mutations in the NLRP3 gene causing familial cold autoinflammatory syndrome (120100), thus demonstrating that ... |