Peripartum cardiomyopathy

General Information (adopted from Orphanet):

Synonyms, Signs: Postpartum cardiomyopathy
Number of Symptoms 36
OrphanetNr: 563
OMIM Id:
ICD-10: O90.3
UMLs: C0269972
C0877208
MeSH:
MedDRA: 10049430
Snomed: 16253001
62377009

Prevalence, inheritance and age of onset:

Prevalence: < 33 of 100 000 - PMID: 26474841 [IBIS]
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: Non-familial dilated cardiomyopathy
 -Rare cardiac disease
Rare disorder related with pregnancy, childbirth and puerperium
 -Rare gynecologic or obstetric disease

Comment:

Heart failure with left ventricular dysfunction occurring during pregnancy or during the post-partum period in patients without history of cardiovascular disease defines peripartum cardiomyopathy (PPCM). PPCM carries a high morbidity and mortality rate as well as the possibility of recovery ad integrum (PMID:26474841).

Symptom Information: Sort by abundance 

1
 (HPO:0100520) Oliguria Occasional [IBIS] 26% (n=19) 26515744 IBIS 14 / 7739
2
 (HPO:0002321) Vertigo 26515744 IBIS 58 / 7739
3
 (HPO:0002315) Headache Occasional [IBIS] 26% (n=19) 26515744 IBIS 175 / 7739
4
 (HPO:0001337) Tremor Occasional [IBIS] 26% (n=19) 26515744 IBIS 200 / 7739
5
 (HPO:0012378) Fatigue Very frequent [IBIS] 74% (n=19) 26515744 IBIS 50 / 7739
6
 (HPO:0100852) Abnormal fear/anxiety-related behavior Occasional [IBIS] 26% (n=19) 26515744 IBIS 2 / 7739
7
 (HPO:0100749) Chest pain Occasional 26% (n=19) 26515744 IBIS 92 / 7739
8
 (HPO:0001785) Ankle swelling Very frequent [IBIS] 79% (n=19) 26515744 IBIS 3 / 7739
9
 (HPO:0002018) Nausea Occasional [IBIS] 26% (n=19) 26515744 IBIS 44 / 7739
10
 (HPO:0004324) Increased body weight 26221550 IBIS 4 / 7739
11
 (HPO:0012664) Reduced ejection fraction 25636745 IBIS 32 / 7739
12
 (HPO:0001635) Congestive heart failure 20675664 IBIS 232 / 7739
13
 (HPO:0005162) Left ventricular failure 25636745 IBIS 18 / 7739
14
 (HPO:0001645) Sudden cardiac death 25636745 IBIS 84 / 7739
15
 (HPO:0001644) Dilated cardiomyopathy 20675664 IBIS 141 / 7739
16
 (HPO:0001637) Abnormality of the myocardium 25636745 IBIS 76 / 7739
17
 (HPO:0004308) Ventricular arrhythmia 3711532 IBIS 46 / 7739
18
 (HPO:0011675) Arrhythmia 20675664 IBIS 226 / 7739
19
 (HPO:0011713) Left bundle branch block 25636745 IBIS 30 / 7739
20
 (HPO:0001962) Palpitations Occasional [IBIS] 26% (n=19) 26515744 IBIS 62 / 7739
21
 (HPO:0003115) Abnormal EKG 20675664 IBIS 44 / 7739
22
 (HPO:0001279) Syncope 26515744 IBIS 94 / 7739
23
 (HPO:0001692) Primary atrial arrhythmia 26002395 IBIS 16 / 7739
24
 (HPO:0001907) Thromboembolism 12560308 IBIS 15 / 7739
25
 (HPO:0001945) Fever Occasional [IBIS] 26% (n=19) 26515744 IBIS 218 / 7739
26
 (HPO:0002094) Dyspnea Very frequent [IBIS] 95% (n=19) 26515744 IBIS 132 / 7739
27
 (OMIM) Bloated face Occasional [IBIS] 26% (n=19) 26515744 IBIS 2 / 7739
28
 (MedDRA:10052333) Electrocardiogram ST-T segment abnormal 20675664 IBIS 5 / 7739
29
 (MedDRA:10071436) Systolic dysfunction 25636745 IBIS 13 / 7739
30
 (MedDRA:10010273) Pregnancy, labour, delivery and postpartum conditions 20675664 IBIS 1 / 7739
31
 (MedDRA:10071660) N-terminal prohormone brain natriuretic peptide abnormal 20675664 IBIS 1 / 7739
32
 (HPO:0012764) Orthopnea 12560308 IBIS 9 / 7739
33
 (MedDRA:10033670) Panic reaction Occasional [IBIS] 26% (n=19) 26515744 IBIS 1 / 7739
34
 (HPO:0012735) Cough Frequent [IBIS] 42% (n=19) 26515744 IBIS 24 / 7739
35
 (MedDRA:10066392) Fear of death Frequent [IBIS] 37% (n=19) 26515744 IBIS 1 / 7739
36
 (HPO:0040086) Abnormal prolactin level 26474841 IBIS 2 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: