Follicular lymphoma

General Information (adopted from Orphanet):

Synonyms, Signs: FL1
Number of Symptoms 15
OrphanetNr: 545
OMIM Id: 613024
ICD-10: C82
UMLs: C0024301
MeSH: D008224
MedDRA:
Snomed: 277618009
308121000
55150002

Prevalence, inheritance and age of onset:

Prevalence: 36 of 100 000 [Orphanet]
Inheritance: Multifactorial
Not applicable
[Orphanet]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Indolent B-cell non-Hodgkin lymphoma
 -Rare hematologic disease
 -Rare oncologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0001357) Plagiocephaly Very frequent [Orphanet] 106 / 7739
2
 (HPO:0001287) Meningitis Occasional [Orphanet] 46 / 7739
3
 (HPO:0001744) Splenomegaly Frequent [Orphanet] 337 / 7739
4
 (HPO:0002585) Abnormality of the peritoneum Occasional [Orphanet] 9 / 7739
5
 (HPO:0004325) Decreased body weight Very frequent [Orphanet] 492 / 7739
6
 (HPO:0000951) Abnormality of the skin Occasional [Orphanet] 147 / 7739
7
 (HPO:0004377) Hematological neoplasm Very frequent [Orphanet] 12 / 7739
8
 (HPO:0012145) Abnormality of multiple cell lineages in the bone marrow Occasional [Orphanet] 11 / 7739
9
 (HPO:0002665) Lymphoma 60 / 7739
10
 (HPO:0001945) Fever Very frequent [Orphanet] 218 / 7739
11
 (HPO:0001004) Lymphedema Occasional [Orphanet] 62 / 7739
12
 (HPO:0002103) Abnormality of the pleura Occasional [Orphanet] 58 / 7739
13
 (HPO:0100721) Mediastinal lymphadenopathy Frequent [Orphanet] 19 / 7739
14
 (HPO:0002716) Lymphadenopathy Very frequent [Orphanet] 129 / 7739
15
 (HPO:0001324) Muscle weakness Frequent [Orphanet] 859 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Follicular non-Hodgkin lymphoma is an indolent B-cell malignancy with an annual incidence exceeding 10,000 cases in the United States (Bohen et al., 2003). One form of susceptibility to follicular lymphoma (FL1) is associated with a region on chromosome ...
Molecular genetics OMIM Conde et al. (2013) presented a method that integrates RNA sequencing (RNA-seq) and allele-specific expression data with genomewide association study (GWAS) data to further characterize SNPs associated with follicular lymphoma. Conde et al. (2013) investigated the influence on ...