Burkitt lymphoma

General Information (adopted from Orphanet):

Synonyms, Signs: BL
Small non-cleaved cell lymphoma
Number of Symptoms 13
OrphanetNr: 543
OMIM Id: 113970
ICD-10: C83.7
UMLs: C0006413
C0079770
MeSH: D002051
D008228
MedDRA: 10006595
10053518
10067184
Snomed: 118617000
22197008
397400006
77381001

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: All ages
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Aggressive B-cell non-Hodgkin lymphoma
 -Rare hematologic disease
 -Rare oncologic disease
Epstein-Barr virus-associated malignant lymphoproliferative disorder
 -Rare oncologic disease

Symptom Information: Sort by abundance 

1
 (MedDRA:10006595) Burkitt's lymphoma 1 / 7739
2
 (OMIM) Ileal, cecal, ovarian, and breast tumors, occasionally (endemic form) 1 / 7739
3
 (OMIM) Elevated lactate dehydrogenase 4 / 7739
4
 (OMIM) Chromosomal translocations involving c-myc (190080, 8q24) and the immunoglobin kappa light chain (147200, 2p12) locus 1 / 7739
5
 (OMIM) 'Starry-sky' pattern 1 / 7739
6
 (OMIM) Jaw and kidney tumor (endemic form) 1 / 7739
7
 (MedDRA:10006596) Burkitt's lymphomas 1 / 7739
8
 (OMIM) Abdominal tumors (immunodeficiency-associated form) 1 / 7739
9
 (OMIM) Monomorphic cells, medium-sized, with round nuclei, multiple nucleoli, and moderate amount of cytoplasm 1 / 7739
10
 (OMIM) Chromosomal translocations involving c-myc (190080, 8q24) and the immunoglobin lambda light chain (147220, 22q11.2) locus 1 / 7739
11
 (HPO:0030080) Burkitt lymphoma 1 / 7739
12
 (OMIM) Chromosomal translocations involving c-myc (190080, 8q24) and the immunoglobin heavy chain (147100, 14q32) locus 1 / 7739
13
 (OMIM) Elevated uric acid 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Burkitt lymphoma is a rare, aggressive B-cell lymphoma that accounts for 30 to 50% of lymphomas in children but only 1 to 2% of lymphomas in adults (Harris and Horning, 2006). It results from chromosomal translocations that involve ...
Clinical Description OMIM Anderson et al. (1986) described 2 sisters in an American family who died of Burkitt lymphoma at ages 11 and 22 years. The mother and 2 healthy brothers had abnormality of lymphocyte subsets. An inherited disturbance of lymphocytes ...
Molecular genetics OMIM Bhatia et al. (1993) screened the MYC gene in a panel of 57 BL biopsies and cell lines and found that 65% had at least 1 amino acid substitution (see, e.g., 190080.0001-190080.0004). The mutations were apparently homozygous in ...