Hereditary geniospasm

General Information (adopted from Orphanet):

Synonyms, Signs: TREMBLING CHIN
GSM1
Hereditary chin-trembling
Hereditary chin myoclonus
Familial trembling of the chin
Number of Symptoms 4
OrphanetNr: 53372
OMIM Id: 190100
ICD-10: G25.3
UMLs: C2931589
MeSH: C537682
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant
[Orphanet]
Age of onset: Childhood
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare genetic tremor disorder
 -Rare genetic disease
Rare tremor disorder
 -Rare neurologic disease

Symptom Information: Sort by abundance 

1
(HPO:0012462) Chin myoclonus 1 / 7739
2
(OMIM) Trembling chin 1 / 7739
3
(OMIM) Intermittent quivering of skin over the chin 1 / 7739
4
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Geniospasm is characterized by spontaneous intermittent involuntary quivering or trembling of the chin that is intensified by stress or anxiety. The movements are first noticed in infancy or childhood and usually abate by late adulthood (Wadlington, 1958; Danek ...
Clinical Description OMIM Wadlington (1958) found geniospasm (trembling chin) with no associated neurologic or other abnormalities in 8 members of 3 generations of a family. Anxiety or emotional upset was a trigger mechanism and tranquilizing and anticonvulsant agents reduced the attacks. ...