Idiopathic neonatal atrial flutter
General Information (adopted from Orphanet):
| Synonyms, Signs: |
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| Number of Symptoms | 8 |
| OrphanetNr: | 45452 |
| OMIM Id: |
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| ICD-10: |
I48 |
| UMLs: |
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| MeSH: |
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| MedDRA: |
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| Snomed: |
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Prevalence, inheritance and age of onset:
| Prevalence: | No data available. |
| Inheritance: |
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| Age of onset: |
Neonatal Infancy 9060798 [IBIS] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Non-genetic cardiac rhythm disease
-Rare cardiac disease |
Comment:
| Idiopathic neonatal atrial flutter (AFL) is characterized by sustained tachycardia in newborns and infants. The majority of patients present with symptoms within the first 48 h of life. (PMID:9060798) |
Symptom Information:
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(HPO:0001629) | Ventricular septal defect | Rare [IBIS] | 9060798 | IBIS | 316 / 7739 | |
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(HPO:0001643) | Patent ductus arteriosus | Rare [IBIS] | 9060798 | IBIS | 228 / 7739 | |
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(HPO:0005150) | Abnormal atrioventricular conduction | Frequent [IBIS] | 64% (n=25) | 9060798 | IBIS | 16 / 7739 |
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(HPO:0004749) | Atrial flutter | Very frequent [IBIS] | 100% (n=25) | 9060798 | IBIS | 20 / 7739 |
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(HPO:0001649) | Tachycardia | Frequent [IBIS] | 80% (n=25) | 9060798 | IBIS | 53 / 7739 |
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(HPO:0001635) | Congestive heart failure | Frequent [IBIS] | 36% (n=25) | 9060798 | IBIS | 232 / 7739 |
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(HPO:0001645) | Sudden cardiac death | Occasional [IBIS] | 8% (n=25) | 9060798 | IBIS | 84 / 7739 |
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(HPO:0001789) | Hydrops fetalis | Occasional [IBIS] | 20% (n=25) | 9060798 | IBIS | 63 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
|---|---|---|---|
| NUP155 | rs587777339 | pathogenic | RCV000114997.3 |