Meniere disease

General Information (adopted from Orphanet):

Synonyms, Signs:
Number of Symptoms 5
OrphanetNr: 45360
OMIM Id: 156000
ICD-10: H81.0
UMLs: C0025281
MeSH: D008575
MedDRA: 10027183
Snomed: 13445001

Prevalence, inheritance and age of onset:

Prevalence: 42.5 of 100 000 [Orphanet]
Inheritance: Unknown
[Orphanet]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare otorhinolaryngologic disease
 -Rare otorhinolaryngologic disease

Symptom Information: Sort by abundance 

1
(HPO:0002321) Vertigo 58 / 7739
2
(HPO:0000365) Hearing impairment 539 / 7739
3
(HPO:0000360) Tinnitus 29 / 7739
4
(OMIM) Episodic vertigo 4 / 7739
5
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Meniere disease is a chronic illness characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural pressure (Sajjadi and Paparella, 2008).
Molecular genetics OMIM Fransen et al. (1999) identified a mutation in the COCH gene (603196.0004) in 1 large Belgian and 2 small Dutch families with autosomal dominant nonsyndromic progressive sensorineural hearing loss associated with vestibular dysfunction (DFNA9; 601369). Greater than 25% ...