Histiocytoid cardiomyopathy
General Information (adopted from Orphanet):
Synonyms, Signs: |
Infantile xanthomatous cardiomyopathy Infantile cardiomyopathy with histiocytoid change Oncocytic cardiomyopathy Foamy myocardial transformation of infancy |
Number of Symptoms | 30 |
OrphanetNr: | 137675 |
OMIM Id: |
212080
500000 |
ICD-10: |
I42.0 |
UMLs: |
C1708371 |
MeSH: |
C535584 |
MedDRA: |
|
Snomed: |
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Prevalence, inheritance and age of onset:
Prevalence: | < 1 of 100 000 |
Inheritance: |
X-linked dominant Autosomal recessive Sporadic 18473377 [IBIS] |
Age of onset: |
|
Disease classification (adopted from Orphanet):
Parent Diseases: |
Cardiomyopathy
-Rare cardiac disease Genetic cardiac rhythm disease -Rare cardiac disease -Rare genetic disease Mitochondrial disease with dilated cardiomyopathy -Rare cardiac disease -Rare genetic disease |
Comment:
Histiocytoid cardiomyopathy (HICMP) is a rare, genetic, cardiac disorder of infancy or childhood, predominantly affecting girls, and clinically manifesting as severe cardiac arrhythmias or dilated cardiomyopathy. Pathoanatomically, HICMP is characterized by subendocardial, epicardial, or valvular yellow-tan nodules, which are histologically built up of abnormal Purkinje fibers and multiple, scattered clusters of histiocytoid myocytes, which are filled with an increased number of normal or abnormal mitochondria. Within the myocardium, yellowish areas with irregular outlines are found and are histologically built up of enlarged, polygonal, histiocyte-like cells with foamy granular cytoplasm (PMID:18473377). |
Symptom Information:
|
(HPO:0008682) | Acute tubular necrosis | 10960495 | IBIS | 4 / 7739 | ||
|
(HPO:0000568) | Microphthalmia | 18473377 | IBIS | 183 / 7739 | ||
|
(HPO:0001087) | Congenital glaucoma | 8617487 | IBIS | 12 / 7739 | ||
|
(HPO:0000659) | Peters anomaly | 8617487 | IBIS | 10 / 7739 | ||
|
(HPO:0007957) | Corneal opacity | 18473377 | IBIS | 84 / 7739 | ||
|
(HPO:0007770) | Hypoplasia of the retina | 18473377 | IBIS | 3 / 7739 | ||
|
(HPO:0001397) | Hepatic steatosis | 10960495 | IBIS | 75 / 7739 | ||
|
(HPO:0001716) | Wolff-Parkinson-White syndrome | 18473377 | IBIS | 21 / 7739 | ||
|
(HPO:0001640) | Cardiomegaly | 25921236 | IBIS | 81 / 7739 | ||
|
(HPO:0001629) | Ventricular septal defect | 21612852 | IBIS | 316 / 7739 | ||
|
(HPO:0001631) | Atria septal defect | 21612852 | IBIS | 274 / 7739 | ||
|
(HPO:0005150) | Abnormal atrioventricular conduction | 18473377 | IBIS | 16 / 7739 | ||
|
(HPO:0001695) | Cardiac arrest | 18473377 | IBIS | 87 / 7739 | ||
|
(HPO:0004756) | Ventricular tachycardia | 25921236 | IBIS | 55 / 7739 | ||
|
(HPO:0004383) | Hypoplastic left heart | 10463272 | IBIS | 29 / 7739 | ||
|
(HPO:0001663) | Ventricular fibrillation | 18473377 | IBIS | 35 / 7739 | ||
|
(HPO:0001645) | Sudden cardiac death | 25921236 | IBIS | 84 / 7739 | ||
|
(HPO:0005152) | Oncocytic cardiomyopathy | 6778813 | IBIS | 2 / 7739 | ||
|
(HPO:0004755) | Supraventricular tachycardia | 10618346 | IBIS | 20 / 7739 | ||
|
(HPO:0011675) | Arrhythmia | 18473377 | IBIS | 226 / 7739 | ||
|
(HPO:0001706) | Endocardial fibroelastosis | 10695541 | IBIS | 20 / 7739 | ||
|
(HPO:0001644) | Dilated cardiomyopathy | 18473377 | IBIS | 141 / 7739 | ||
|
(HPO:0001637) | Abnormality of the myocardium | 10960495 | IBIS | 76 / 7739 | ||
|
(HPO:0001635) | Congestive heart failure | 18473377 | IBIS | 232 / 7739 | ||
|
(HPO:0011923) | Decreased activity of mitochondrial complex I | 15164143 | IBIS | 35 / 7739 | ||
|
(HPO:0003756) | Skeletal myopathy | 8563940 | IBIS | 8 / 7739 | ||
|
(HPO:0001274) | Agenesis of corpus callosum | 12900578 | IBIS | 142 / 7739 | ||
|
(HPO:0030682) | Left ventricular noncompaction | 15892002 | IBIS | 4 / 7739 | ||
|
(HPO:0040014) | Increased mitochondrial number | 15164143 | IBIS | 3 / 7739 | ||
|
(HPO:0000238) | Hydrocephalus | 18473377 | IBIS | 278 / 7739 |
Associated genes:
MTCYB; MTTK; CACNA2D1; RANGRF; |
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
---|---|---|---|
MT-CYB | rs207460003 | pathogenic | RCV000010322.2 |