Anti-glomerular basement membrane disease

General Information (adopted from Orphanet):

Synonyms, Signs: Goodpasture syndrome
Anti-GBM syndrome
Number of Symptoms 24
OrphanetNr: 375
OMIM Id: 233450
ICD-10: M31.0
UMLs:
MeSH:
MedDRA: 10018620
Snomed: 50581000

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: Adolescent
Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Secondary glomerular disease
 -Rare renal disease
Secondary interstitial lung disease in childhood and adulthood associated with a systemic disease
 -Rare respiratory disease

Symptom Information: Sort by abundance 

1
 (HPO:0000099) Glomerulonephritis 13 / 7739
2
 (HPO:0100820) Glomerulopathy Very frequent [Orphanet] 46 / 7739
3
 (HPO:0000790) Hematuria Frequent [Orphanet] 106 / 7739
4
 (HPO:0000083) Renal insufficiency Occasional [Orphanet] 232 / 7739
5
 (HPO:0000093) Proteinuria Very frequent [Orphanet] 169 / 7739
6
 (HPO:0000541) Retinal detachment Occasional [Orphanet] 87 / 7739
7
 (HPO:0100749) Chest pain Very frequent [Orphanet] 92 / 7739
8
 (HPO:0100769) Synovitis Occasional [Orphanet] 86 / 7739
9
 (HPO:0005059) Arthralgia/arthritis Occasional [Orphanet] 141 / 7739
10
 (HPO:0001933) Subcutaneous hemorrhage Occasional [Orphanet] 50 / 7739
11
 (HPO:0012089) Arteritis Very frequent [Orphanet] 40 / 7739
12
 (HPO:0001903) Anemia Very frequent [Orphanet] 289 / 7739
13
 (HPO:0001945) Fever Occasional [Orphanet] 218 / 7739
14
 (HPO:0002105) Hemoptysis Very frequent [Orphanet] 30 / 7739
15
 (HPO:0002088) Abnormality of lung morphology Very frequent [Orphanet] 11 / 7739
16
 (HPO:0002093) Respiratory insufficiency Very frequent [Orphanet] 410 / 7739
17
 (HPO:0002094) Dyspnea 132 / 7739
18
 (HPO:0002113) Pulmonary infiltrates Very frequent [Orphanet] 36 / 7739
19
 (HPO:0002960) Autoimmunity Very frequent [Orphanet] 78 / 7739
20
 (HPO:0003326) Myalgia Occasional [Orphanet] 143 / 7739
21
 (OMIM) Circulating antibodies to alpha-3 chain of type IV collagen 1 / 7739
22
 (MedDRA:10037394) Pulmonary haemorrhage 2 / 7739
23
 (HPO:0000007) Autosomal recessive inheritance 2538 / 7739
24
 ([DEL]MedDRA:10011224) Cough Very frequent [Orphanet] 70 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Goodpasture syndrome is an autoimmune disease of lung and kidney. Viral and streptococcal infections and exposure to hydrocarbon fumes have been suggested as possible causes. Three familial instances (Gossain et al., 1972; Maddock et al., 1967), including a ...