Legius syndrome

General Information (adopted from Orphanet):

Synonyms, Signs: NEUROFIBROMATOSIS TYPE 1-LIKE SYNDROME
NFLS
NF1-like syndrome
Neurofibromatosis 1-like syndrome
Number of Symptoms 31
OrphanetNr: 137605
OMIM Id: 611431
ICD-10: Q85.0
UMLs: C1969623
MeSH: C548032
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant
[Orphanet]
Age of onset: Neonatal
Infancy
Childhood
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Genetic hyperpigmentation of the skin
 -Rare genetic disease
Hyperpigmentation of the skin
 -Rare skin disease
Malformation syndrome with hamartosis
 -Rare developmental defect during embryogenesis
 -Rare genetic disease

Symptom Information: Sort by abundance 

1
(HPO:0000470) Short neck 345 / 7739
2
(HPO:0000218) High palate 356 / 7739
3
(HPO:0000347) Micrognathia 426 / 7739
4
(HPO:0000316) Hypertelorism 644 / 7739
5
(HPO:0000286) Epicanthus 371 / 7739
6
(HPO:0000256) Macrocephaly 298 / 7739
7
(HPO:0000325) Triangular face 91 / 7739
8
(HPO:0002162) Low posterior hairline 88 / 7739
9
(HPO:0000494) Downslanted palpebral fissures 328 / 7739
10
(HPO:0004482) Relative macrocephaly 44 / 7739
11
(HPO:0000508) Ptosis 459 / 7739
12
(HPO:0000368) Low-set, posteriorly rotated ears 38 / 7739
13
(HPO:0001067) Neurofibromas 7 / 7739
14
(HPO:0000752) Hyperactivity 140 / 7739
15
(HPO:0001328) Specific learning disability 114 / 7739
16
(HPO:0007018) Attention deficit hyperactivity disorder 56 / 7739
17
(HPO:0000766) Abnormality of the sternum rare [HPO:skoehler] 31 / 7739
18
(HPO:0000957) Cafe-au-lait spot 84 / 7739
19
(HPO:0000997) Axillary freckling 9 / 7739
20
(HPO:0001012) Multiple lipomas 43 / 7739
21
(HPO:0001324) Muscle weakness 859 / 7739
22
(HPO:0008947) Infantile muscular hypotonia 482 / 7739
23
(HPO:0001252) Muscular hypotonia 990 / 7739
24
(HPO:0010547) Muscle flaccidity 466 / 7739
25
(OMIM) No neurofibromas 2 / 7739
26
(OMIM) High peaks of upper lip vermilion border 2 / 7739
27
(HPO:0001355) Megalencephaly 39 / 7739
28
(OMIM) Noonan-like facies in a minority of patients 1 / 7739
29
(OMIM) Triangular face with age 2 / 7739
30
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
31
(OMIM) Deeply grooved philtrum 2 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Legius syndrome is an autosomal dominant disorder that shows some similarities to neurofibromatosis type I (NF1; 162200), which is caused by mutation in the neurofibromin gene (613113); however, Legius syndrome is less severe. Individuals with Legius syndrome typically ...
Clinical Description OMIM Brems et al. (2007) described 5 families with an autosomal dominant trait consisting of multiple cafe-au-lait spots, axillary freckling, macrocephaly, and a Noonan (163950)-like facial dysmorphism in some individuals. Despite the phenotypic similarities to neurofibromatosis type I, none ...
Molecular genetics OMIM In affected members of 5 unrelated families with an autosomal dominant phenotype referred to as neurofibromatosis type 1-like syndrome, Brems et al. (2007) identified 4 different heterozygous mutations in the SPRED1 gene (609291.0001-609291.0004). Screening of 86 additional patients ...
Diagnosis GeneReviews The cardinal feature of Legius syndrome is pigmentary dysplasia consisting of café au lait macules, with or without intertriginous freckling. ...
Clinical Description GeneReviews The natural history of Legius syndrome is based on the clinical manifestations of a few series of individuals with SPRED1 mutations and their extended families (summarized in the bulleted list that follows). Additional less common manifestations are listed in Table 2. Better delineation of the clinical manifestations and natural history of Legius syndrome will likely occur as more affected individuals are identified and followed prospectively....
Genotype-Phenotype Correlations GeneReviews A variety of pathologic allelic variants (e.g., missense, nonsense, frameshift, splice-site) throughout SPRED1 have been reported. To date no genotype-phenotype correlations have been documented....
Differential Diagnosis GeneReviews Of primary importance in the clinical delineation of Legius syndrome is establishing the absence of other manifestations associated with the large number of other syndromes with multiple café au lait macules. Although the diagnosis of Legius syndrome is difficult to make clinically with certainty without identification of a disease-causing SPRED1 mutation, the lack of additional clinical features can help to differentiate Legius syndrome from other conditions. ...
Management GeneReviews To establish the extent of disease and needs of an individual with a confirmed molecular diagnosis of Legius syndrome, the following evaluations are recommended: ...
Molecular genetics GeneReviews Information in the Molecular Genetics and OMIM tables may differ from that elsewhere in the GeneReview: tables may contain more recent information. —ED....