Testicular teratoma

General Information (adopted from Orphanet):

Synonyms, Signs: EMBRYONAL CELL CARCINOMA, INCLUDED
SPERMATOCYTIC SEMINOMA, INCLUDED
MALE GERM CELL TUMOR
ENDODERMAL SINUS TUMOR, INCLUDED
NONSEMINOMATOUS GERM CELL TUMORS, INCLUDED
MGCT SEMINOMA, INCLUDED
TERATOMA, TESTICULAR, INCLUDED
TGCT
Teratoma of the testis
Number of Symptoms 14
OrphanetNr: 363483
OMIM Id: 273300
ICD-10: C62
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Sporadic
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: Testicular and paratesticular tumor
 -Rare oncologic disease
 -Rare urogenital disease

Symptom Information: Sort by abundance 

1
(HPO:0000133) Gonadal dysgenesis 21 / 7739
2
(HPO:0009792) Teratoma 7 / 7739
3
(HPO:0000028) Cryptorchidism 347 / 7739
4
(HPO:0001939) Abnormality of metabolism/homeostasis 328 / 7739
5
(OMIM) Azoospermia/oligospermia (present at diagnosis) 6 / 7739
6
(HPO:0003745) Sporadic 131 / 7739
7
(OMIM) Elevated hCG or AFP or both (embryonal carcinoma) 6 / 7739
8
(MedDRA:10039956) Seminoma 7 / 7739
9
(OMIM) Painless testicular mass 6 / 7739
10
(OMIM) Nonseminoma (embryonal carcinoma, teratoma, choriocarcinoma, endodermal sinus tumor) 6 / 7739
11
(OMIM) Elevated hCG (choriocarcinoma) 6 / 7739
12
(OMIM) Isochromosome 12p (i(12p)) 6 / 7739
13
(OMIM) Male germ cell tumors (GCT), 2 subtypes - 6 / 7739
14
(OMIM) Elevated AFP (endodermal sinus tumor) 6 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Testicular germ cell tumors (TGCTs) affect 1 in 500 men and are the most common cancer in males aged 15 to 40 in western European populations. The incidence of TGCT rose dramatically during the 20th century. Known risk ...
Clinical Description OMIM Hutter et al. (1967) reviewed the reports of testicular tumors in brothers and in twins and reported affected brothers.

Gustavson et al. (1975) reported bilateral testicular teratoma in 2 infant brothers with XXY Klinefelter syndrome. One ...

Molecular genetics OMIM

- Variation in the BCL10 Gene and Progression to Advanced Stage TGCT

Inoue et al. (2006) analyzed 4 SNPs in the BCL10 gene on chromosome 1p22, which had previously been identified in Japanese TGCTs ...

Population genetics OMIM Forman et al. (1992) reported an epidemiologic study that showed an 8- to 10-fold increase in relative risk of testicular cancer to brothers of patients and a 4-fold increase in risk to fathers and sons. Families with multiple ...